Researchers from Mount Sinai School of Medicine have found high levels of food toxins called Advanced Glycation End products (AGEs) in infants. Excessive food AGEs, through both maternal blood transmission and baby formula, could together significantly increase children's risk for diseases such as diabetes from a very young age.
A second study of AGEs in adults found that cutting back on processed, grilled, and fried foods, which are high in AGEs, may improve insulin resistance in people with diabetes. AGEs -- toxic glucose byproducts previously tied to high blood sugar -- are found in most heated foods and, in great excess, in commercial infant formulas.
The first report, published in Diabetes Care in December 2010, showed that AGEs can be elevated as early as at birth, indicating that infants are highly susceptible to the inflammation associated with insulin resistance and diabetes later in life. Helen Vlassara, MD, Professor and Director of the Division of Experimental Diabetes and Aging, working with Jaime Uribarri, MD, Professor of Medicine and colleagues at Mount Sinai School of Medicine, looked at 60 women and their infants to see if there was a passive transfer of AGEs from the blood of mothers to their babies. They found that newborn infants, expected to be practically AGE-free, had levels of AGEs in their blood as high as their adult mothers.
Within the first year of life, after switching from breast milk onto commercial formulas, the infants' AGEs had doubled to levels seen in people with diabetes, and many had elevated insulin levels. Formulas that are processed under high heat can contain 100 times more AGEs than human breast milk, delivering a huge AGE surplus to infants, which could be toxic.
"Modern food AGEs can overwhelm the body's defenses, a worrisome fact especially for young children," said Dr. Vlassara. "More research is certainly needed, but the findings confirm our studies in genetic animal models of diabetes. Given the rise in the incidence of diabetes in children, safe and low cost AGE-less approaches to children's diet should be considered by clinicians and families."
The work led to a second report in Diabetes Care, in July 2011, which demonstrates that a modest cut in foods high in AGEs may improve insulin resistance in adults with diabetes. AGEs were found to be elevated in most grilled, fried, or baked foods. Cutting back on the consumption of foods that are heat-processed, but without reducing fat or carbohydrate consumption, improved insulin levels and overall health in patients already treated for, but remaining, insulin resistant. The findings are a dramatic departure from standard clinical recommendations for the management of diabetes.
For four months, 18 overweight people with type 2 diabetes and 18 healthy adults were assigned to an AGE-restricted diet or a standard diet consisting of the same calories and nutrients they ingested before beginning the AGE-restricted diet. An AGE-restricted diet emphasizes poached or stewed foods, such as mashed potatoes instead of fries, stewed chicken instead of grilled chicken, and boiled eggs instead of fried eggs.
The results showed that the subjects with diabetes assigned to the AGE-restricted diet had a 35 percent decrease in blood insulin levels, well beyond that achieved by their previous therapeutic regimen. This was associated with improved markers of inflammation and a restoration of compromised native defenses. This is the first study to show in humans that AGEs promote insulin resistance and possibly diabetes. The study also shows for the first time that restricting the amount of AGEs consumed with food may quickly restore the body's defenses and reduce insulin resistance.
"This clinical study begins to expose the double role food AGEs play in obesity and in diabetes, a major concern for everyone today, particularly young children. It is especially exciting that a simple intervention such as AGE-restriction or future drugs that block AGE absorption could have a positive effect on these epidemics," said Dr. Vlassara. "The tenets of the diet could not be simpler; turn down the heat, add water, and eat more at home."
Dr. Vlassara's laboratory has been under the support of a NIA MERIT grant, a NIDDK grant and a National Institute of Research Resources grant.
Mount Sinai Press Office | EurekAlert!
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
25.05.2018 | Event News
02.05.2018 | Event News
13.04.2018 | Event News
25.05.2018 | Event News
25.05.2018 | Machine Engineering
25.05.2018 | Life Sciences