Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study shows importance of exercise for those at special risk for Alzheimer's

19.11.2010
Participants included individuals who carry a high-risk gene

Physical activity promotes changes in the brain that may protect high-risk individuals against cognitive decline, including development of Alzheimer's disease, according to a new study done at the University of Wisconsin-Milwaukee (UWM).

J. Carson Smith, an assistant professor of health sciences, included in the study both people who carry a high-risk gene for Alzheimer's disease, and other healthy older adults without the gene.

"Our study suggests that if you are at genetic risk for Alzheimer's disease, the benefits of exercise to your brain function might be even greater than for those who do not have that genetic risk," says Smith.

While evidence already shows that physical activity is associated with maintenance of cognitive function across a life span, most of this research has been done with healthy people, without any consideration of their level of risk for Alzheimer's, says Smith.

A team of researchers compared brain activation during memory processing in four separate groups of healthy 65- to 85-years-olds. The level of risk was defined by whether an individual carried the apolipoprotein E-epsilon4 (APOE–ϵ4) allele. Physical activity status was defined by how much and how often the participants reported physical activity (PA). The study divided subjects into Low Risk/Low PA, Low Risk/High PA, High Risk/Low PA and High Risk/High PA.

Functional magnetic resonance imaging (fMRI) was used to measure brain activation of participants while they performed a mental task involving discriminating among famous people. This test is very useful, says Smith, because it engages a wide network called the semantic memory system, with activation occurring in 15 different functional regions of the brain.

"When a person thinks about people – for example, Frank Sinatra or Lady Gaga – that involves several lobes of the brain," explains Smith.

In the study groups of those carrying the gene, individuals who exercised showed greater brain activity in memory-related regions than those who were sedentary.

Perhaps even more intriguing, physically active people with the gene had greater brain activity than those who were physically active but not gene carriers.

There are many physiological reasons why this could be happening, Smith says. "For example, people with this increased activation might be compensating for some underlying neurological event that is involved in cognitive decline.". "Using more areas of their brain may serve as a protective function, even in the face of disease processes."

The study's collaborating institutions include the Cleveland Clinic, Marquette University, Wayne State University and Rosalind Franklin University of Medicine and Science. It was funded by the National Institutes of Health and the National Institute on Aging.

The study will be published in Vol. 54 (January 2011) of the journal NeuroImage, but is now available online.

Smith's current research builds on this study. He and his team are conducting a new study testing the before-and-after effects of a structured exercise program on brain function. The study includes patients diagnosed with mild cognitive impairment or early Alzheimer's disease, as well as a healthy control group.

For more information on this ongoing study, visit http://www.exerciseforbrainhealth.com/

J. Carson Smith | EurekAlert!
Further information:
http://www.uwm.edu

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>