Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study shows importance of exercise for those at special risk for Alzheimer's

19.11.2010
Participants included individuals who carry a high-risk gene

Physical activity promotes changes in the brain that may protect high-risk individuals against cognitive decline, including development of Alzheimer's disease, according to a new study done at the University of Wisconsin-Milwaukee (UWM).

J. Carson Smith, an assistant professor of health sciences, included in the study both people who carry a high-risk gene for Alzheimer's disease, and other healthy older adults without the gene.

"Our study suggests that if you are at genetic risk for Alzheimer's disease, the benefits of exercise to your brain function might be even greater than for those who do not have that genetic risk," says Smith.

While evidence already shows that physical activity is associated with maintenance of cognitive function across a life span, most of this research has been done with healthy people, without any consideration of their level of risk for Alzheimer's, says Smith.

A team of researchers compared brain activation during memory processing in four separate groups of healthy 65- to 85-years-olds. The level of risk was defined by whether an individual carried the apolipoprotein E-epsilon4 (APOE–ϵ4) allele. Physical activity status was defined by how much and how often the participants reported physical activity (PA). The study divided subjects into Low Risk/Low PA, Low Risk/High PA, High Risk/Low PA and High Risk/High PA.

Functional magnetic resonance imaging (fMRI) was used to measure brain activation of participants while they performed a mental task involving discriminating among famous people. This test is very useful, says Smith, because it engages a wide network called the semantic memory system, with activation occurring in 15 different functional regions of the brain.

"When a person thinks about people – for example, Frank Sinatra or Lady Gaga – that involves several lobes of the brain," explains Smith.

In the study groups of those carrying the gene, individuals who exercised showed greater brain activity in memory-related regions than those who were sedentary.

Perhaps even more intriguing, physically active people with the gene had greater brain activity than those who were physically active but not gene carriers.

There are many physiological reasons why this could be happening, Smith says. "For example, people with this increased activation might be compensating for some underlying neurological event that is involved in cognitive decline.". "Using more areas of their brain may serve as a protective function, even in the face of disease processes."

The study's collaborating institutions include the Cleveland Clinic, Marquette University, Wayne State University and Rosalind Franklin University of Medicine and Science. It was funded by the National Institutes of Health and the National Institute on Aging.

The study will be published in Vol. 54 (January 2011) of the journal NeuroImage, but is now available online.

Smith's current research builds on this study. He and his team are conducting a new study testing the before-and-after effects of a structured exercise program on brain function. The study includes patients diagnosed with mild cognitive impairment or early Alzheimer's disease, as well as a healthy control group.

For more information on this ongoing study, visit http://www.exerciseforbrainhealth.com/

J. Carson Smith | EurekAlert!
Further information:
http://www.uwm.edu

More articles from Studies and Analyses:

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

nachricht A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>