Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study shows image fusion-guided biopsy improves accuracy of prostate cancer diagnosis

22.05.2014

A recent study by investigators from LIJ Medical Center demonstrated that using magnetic resonance imaging (MRI) in men with an elevated prostate specific antigen (PSA) resulted in a prostate cancer detection rate that was twice as high as data reported in the March 1999 Prostate journal that analyzed men undergoing the standard 12-core biopsy with an elevated PSA. Physicians in the recent trial used a targeted approach to evaluate prostate cancer that combines MR imaging and transrectal ultrasound fusion guided prostate biopsy.

Given the limitations of the PSA blood test and the standard 12-core ultrasound biopsies for detecting prostate cancer, researchers evaluated the initial 105 men eligible for the clinical trial using a new targeted prostate fusion biopsy method.

The study, which will appear in the June issue of the Journal of Urology, showed that prostate cancer was detected in 62 percent of men tested in the latest trial vs. 30 percent in the general population as reported in the 1999 Prostate journal.

"The results of the phase III clinical trial show that a target fusion biopsy detects more clinically significant prostate cancer," said Art Rastinehad, DO, principal investigator of the study and director of interventonal urologic oncology at North Shore-LIJ's Arthur Smith Institute for Urology, in New Hyde Park, NY. "This is the type of cancer that patients may benefit from treatment compared to other patients with low grade and low volume prostate cancer."

Investigators used the UroNav system, which combines MRI and ultrasound imaging to better identify areas not revealed by the standard, 12-core biopsy procedure. A field generator, similar to a GPS device, is placed over the patient's hip to guide the biopsy. The MRI and ultrasound images are overlaid in real-time, which provide an evaluation of 100 percent of the prostate gland to get the most accurate diagnosis possible.

"The study also showed that in situations when the 12-core biopsy did not detect cancer, the fusion biopsy detected cancer in 15 percent of cases and in these cases, 85 percent were clinically significant," Dr. Rastinehad said.

Dr. Rastinehad credits the quality of the multiparametric prostate MR imaging as one of the key factors in the outcomes of the study, which resulted in excellent prostate cancer detection rates as compared to data from other institutions using the fusion biopsy technology.

"The MRI creates the road map to target specific areas within the prostate," Dr Rastinehad said. "Some patients with previous multiple negative prostate biopsies have cancer outside the usual areas sampled on the standard biopsy so the new technology takes away the mystery of a diagnosis."

Dr. Rastinehad noted the challenge in the study was trying to reproduce the high quality MRI results the National Institutes of Health has established, extending thanks for researches there for assistance in LIJ's research.

"Our study results are very promising," Dr. Rastinehad. "There is no question that a targeted approach will yield more cancer and actually more clinical significant cancer. Our next challenge is to perform a randonmized control trial to see if MR imaging for screening combined with a fusion biopsy can be applied to the broader patient population."

###

To view the abstract: "Improving Detection of Clinically Significant Prostate Cancer: Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Guided Prostate Biopsy."

A copy of the study is available is available on request.

Acknowledgements: Invivo provided research equipment. NIH Molecular Imaging Program, Urological Oncology Branch and Center for Image Guided Oncology assisted with initial program support.

Betty Olt | Eurek Alert!

Further reports about: Island MRI Oncology biopsies biopsy diagnosis prostate significant

More articles from Studies and Analyses:

nachricht Study suggests new way of preventing diabetes-associated blindness
26.05.2015 | Johns Hopkins Medicine

nachricht Memories Influence Choice of Food
22.05.2015 | Universität Basel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Lasers are the key to mastering challenges in lightweight construction

Many joining and cutting processes are possible only with lasers. New technologies make it possible to manufacture metal components with hollow structures that are significantly lighter and yet just as stable as solid components. In addition, lasers can be used to combine various lightweight construction materials and steels with each other. The Fraunhofer Institute for Laser Technology ILT in Aachen is presenting a range of such solutions at the LASER World of Photonics trade fair from June 22 to 25, 2015 in Munich, Germany, (Hall A3, Stand 121).

Lightweight construction materials are popular: aluminum is used in the bodywork of cars, for example, and aircraft fuselages already consist in large part of...

Im Focus: Solid-state photonics goes extreme ultraviolet

Using ultrashort laser pulses, scientists in Max Planck Institute of Quantum Optics have demonstrated the emission of extreme ultraviolet radiation from thin dielectric films and have investigated the underlying mechanisms.

In 1961, only shortly after the invention of the first laser, scientists exposed silicon dioxide crystals (also known as quartz) to an intense ruby laser to...

Im Focus: Advance in regenerative medicine

The only professorship in Germany to date, one master's programme, one laboratory with worldwide unique equipment and the corresponding research results: The University of Würzburg is leading in the field of biofabrication.

Paul Dalton is presently the only professor of biofabrication in Germany. About a year ago, the Australian researcher relocated to the Würzburg department for...

Im Focus: Basel Physicists Develop Efficient Method of Signal Transmission from Nanocomponents

Physicists have developed an innovative method that could enable the efficient use of nanocomponents in electronic circuits. To achieve this, they have developed a layout in which a nanocomponent is connected to two electrical conductors, which uncouple the electrical signal in a highly efficient manner. The scientists at the Department of Physics and the Swiss Nanoscience Institute at the University of Basel have published their results in the scientific journal “Nature Communications” together with their colleagues from ETH Zurich.

Electronic components are becoming smaller and smaller. Components measuring just a few nanometers – the size of around ten atoms – are already being produced...

Im Focus: IoT-based Advanced Automobile Parking Navigation System

Development and implementation of an advanced automobile parking navigation platform for parking services

To fulfill the requirements of the industry, PolyU researchers developed the Advanced Automobile Parking Navigation Platform, which includes smart devices,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International symposium: trends in spatial analysis and modelling for a more sustainable land use

20.05.2015 | Event News

15th conference of the International Association of Colloid and Interface Scientists

18.05.2015 | Event News

EHFG 2015: Securing health in Europe. Balancing priorities, sharing responsibilities

12.05.2015 | Event News

 
Latest News

Quasi-sexual gene transfer drives genetic diversity of hot spring bacteria

29.05.2015 | Life Sciences

First Eastern Pacific tropical depression runs ahead of dawn

29.05.2015 | Earth Sciences

Donuts, math, and superdense teleportation of quantum information

29.05.2015 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>