New research published today in the American Journal of Psychiatry indicates a strong link between subthreshold manic episodes and likelihood of developing bipolar disorder in children of parents with bipolar disorder. The study's findings could improve clinical assessment and care for these high-risk children by potentially enabling earlier identification, treatment or possible preventive measures.
The study is among the first to show that subthreshold manic episodes -- experiences that approach but do not meet the cut-offs for full-blown bipolar disorder -- are important diagnostic risk factors for the development of bipolar disorder and other mental health conditions in high-risk children. In addition, it found that children of parents with bipolar disorder have substantially higher rates of subthreshold mania or hypomania (13.3 vs 1.2 percent); manic, mixed or hypomanic episodes (9.2 vs 0.8 percent); and major depressive episodes (32.0 vs 14.9 percent) than community children.
"Mental health practitioners should carefully assess for short episodes of manic symptoms, major depression and disruptive behavior disorders in high-risk children, as these are risk factors for the future onset of bipolar disorder," said David Axelson, MD, medical director of Behavioral Health at Nationwide Children's Hospital and senior author on the study. "This may be particularly important if medication is going to be used for treating mood or behavioral symptoms in the child, because some medications might increase the risk of developing mania or psychotic symptoms in someone who is already at very high risk for developing bipolar disorder. Prescribers might choose different medication options, or use lower doses and monitor for problems more closely."
The cumulative rate of bipolar spectrum disorders at age 21 was 23 percent in the high-risk group compared to 3.2 percent in the comparison group. The mean age of onset for a bipolar spectrum disorder was 12 years, with the earliest manic episode being documented at 8 years, highlighting the importance of monitoring subthreshold symptoms for early intervention.
"Most children who have a parent with bipolar disorder will have a diagnosable psychiatric disorder, such as attention-deficit disorder, oppositional defiant disorder, an anxiety disorder or depression, at some point during their youth," said Dr. Axelson, who is also a professor of clinical psychiatry at The Ohio State University. "However, most children who have a parent with bipolar disorder do not develop bipolar disorder."
Among the study's high-risk children who did develop bipolar disorder, nearly all had identifiable mood episodes and other psychiatric disorders before the onset of full-fledged bipolar illness.
"Short, distinct episodes of manic symptoms were the most specific predictor of developing bipolar disorder in high-risk offspring," Dr. Axelson said. "But so far, many children with these short manic episodes have not progressed to full-fledged bipolar disorder."
This study is part of the Pittsburgh Bipolar Offspring Study (BIOS), which is the largest study to date of children of parents with bipolar disorder. Unique to BIOS is the assessment of children for subthreshold episodes of manic symptoms. This latest publication confirms and extends the baseline findings and describes how mood episodes develop in an effort to aid in early diagnosis on the basis of those subthreshold episodes.
The longitudinal study followed high-risk children and demographically matched offspring of community parents. Follow-up interviews were completed in 91 percent of the offspring with a mean follow-up duration of 6.8 years. The initial and follow-up interviews were conducted using the Structured Clinical Interview for DSM-IV (parents) and the Schedule for Affective Disorders and Schizophrenia for School-Age Children (children). Follow-ups focused on the assessment of the interval since the previous interview.
"I am continuing to collaborate with researchers on the Pittsburgh Bipolar Offspring Study," Dr. Axelson said. "We expect to find more exciting results that will impact the diagnosis and treatment of high-risk children as we follow the participants into young adulthood."
Axelson D, Goldstein B, Goldstein T, Monk K, Yu H, Hickey MB, Sakolsky D, Diler R, Hafeman D, Merranko J, Iyengar S, Brent D, Kupfer D, Birmaher B. Diagnostic precursors to bipolar disorder in offspring of parents with bipolar disorder: A longitudinal study. American Journal of Psychiatry. 2015 Mar. doi: 10.1176/appi.ajp.2014.14010035.
Danielle Warner | EurekAlert!
Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
23.06.2017 | Physics and Astronomy
23.06.2017 | Physics and Astronomy
23.06.2017 | Information Technology