Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study offers clues to early detection of bipolar disorders in high-risk children

03.03.2015

New research published today in the American Journal of Psychiatry indicates a strong link between subthreshold manic episodes and likelihood of developing bipolar disorder in children of parents with bipolar disorder. The study's findings could improve clinical assessment and care for these high-risk children by potentially enabling earlier identification, treatment or possible preventive measures.

The study is among the first to show that subthreshold manic episodes -- experiences that approach but do not meet the cut-offs for full-blown bipolar disorder -- are important diagnostic risk factors for the development of bipolar disorder and other mental health conditions in high-risk children. In addition, it found that children of parents with bipolar disorder have substantially higher rates of subthreshold mania or hypomania (13.3 vs 1.2 percent); manic, mixed or hypomanic episodes (9.2 vs 0.8 percent); and major depressive episodes (32.0 vs 14.9 percent) than community children.

"Mental health practitioners should carefully assess for short episodes of manic symptoms, major depression and disruptive behavior disorders in high-risk children, as these are risk factors for the future onset of bipolar disorder," said David Axelson, MD, medical director of Behavioral Health at Nationwide Children's Hospital and senior author on the study. "This may be particularly important if medication is going to be used for treating mood or behavioral symptoms in the child, because some medications might increase the risk of developing mania or psychotic symptoms in someone who is already at very high risk for developing bipolar disorder. Prescribers might choose different medication options, or use lower doses and monitor for problems more closely."

The cumulative rate of bipolar spectrum disorders at age 21 was 23 percent in the high-risk group compared to 3.2 percent in the comparison group. The mean age of onset for a bipolar spectrum disorder was 12 years, with the earliest manic episode being documented at 8 years, highlighting the importance of monitoring subthreshold symptoms for early intervention.

"Most children who have a parent with bipolar disorder will have a diagnosable psychiatric disorder, such as attention-deficit disorder, oppositional defiant disorder, an anxiety disorder or depression, at some point during their youth," said Dr. Axelson, who is also a professor of clinical psychiatry at The Ohio State University. "However, most children who have a parent with bipolar disorder do not develop bipolar disorder."

Among the study's high-risk children who did develop bipolar disorder, nearly all had identifiable mood episodes and other psychiatric disorders before the onset of full-fledged bipolar illness.

"Short, distinct episodes of manic symptoms were the most specific predictor of developing bipolar disorder in high-risk offspring," Dr. Axelson said. "But so far, many children with these short manic episodes have not progressed to full-fledged bipolar disorder."

This study is part of the Pittsburgh Bipolar Offspring Study (BIOS), which is the largest study to date of children of parents with bipolar disorder. Unique to BIOS is the assessment of children for subthreshold episodes of manic symptoms. This latest publication confirms and extends the baseline findings and describes how mood episodes develop in an effort to aid in early diagnosis on the basis of those subthreshold episodes.

The longitudinal study followed high-risk children and demographically matched offspring of community parents. Follow-up interviews were completed in 91 percent of the offspring with a mean follow-up duration of 6.8 years. The initial and follow-up interviews were conducted using the Structured Clinical Interview for DSM-IV (parents) and the Schedule for Affective Disorders and Schizophrenia for School-Age Children (children). Follow-ups focused on the assessment of the interval since the previous interview.

"I am continuing to collaborate with researchers on the Pittsburgh Bipolar Offspring Study," Dr. Axelson said. "We expect to find more exciting results that will impact the diagnosis and treatment of high-risk children as we follow the participants into young adulthood."

###

Citation:

Axelson D, Goldstein B, Goldstein T, Monk K, Yu H, Hickey MB, Sakolsky D, Diler R, Hafeman D, Merranko J, Iyengar S, Brent D, Kupfer D, Birmaher B. Diagnostic precursors to bipolar disorder in offspring of parents with bipolar disorder: A longitudinal study. American Journal of Psychiatry. 2015 Mar. doi: 10.1176/appi.ajp.2014.14010035.

Danielle Warner | EurekAlert!

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

Light rays from a supernova bent by the curvature of space-time around a galaxy

21.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>