Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study May Lead to Improved Treatment for Lung Disease

12.07.2011
National Study Led by Researchers from Intermountain Medical Center May Lead to Earlier Diagnosis, Improved Treatment for Patients Suffering from Fatal Lung Disease

One-fifth of all patients with pulmonary arterial hypertension suffer with the fatal disease for more than two years before being correctly diagnosed and properly treated, according to a new national study led by researchers at Intermountain Medical Center in Murray, Utah.

"For a lot of patients, that means the treatment is more difficult and the damage is irreversible," said Lynnette Brown, MD, PhD, a pulmonologist and researcher at Intermountain Medical Center and lead author of the study, which is published this week in the July issue of Chest, the journal of the American College of Chest Physicians.

"Finding out which patients are getting a delayed diagnosis is the first step in identifying them earlier, when treatment is easier and hopefully more effective," she said.

Pulmonary arterial hypertension (PAH) is a rare but fatal disease that occurs when small arteries in the lungs become narrowed and unable to carry as much blood as healthy arteries. Pressure builds as the heart works harder to move blood into the lungs. Eventually, the heart may fail.

Treatment options have improved, extending the lives of many patients. But treatment may be less effective for patients who receive a delayed diagnosis.

The study found that:

More than 21 percent of patients with PAH had symptoms for over two years before being diagnosed and beginning treatment.

Patients younger than 36 years old were most likely to receive a delayed diagnosis.

Patients who previously had been diagnosed with a common respiratory disorder such as obstructive airway disease or sleep apnea were also more likely to have a delayed diagnosis.

Dr. Brown and her colleagues gave several possible reasons for delayed diagnosis:

Symptoms — shortness of breath, fatigue, swelling, and chest pain — can also point to more common disorders, such as asthma.

Younger patients are typically more active than older patients and notice symptoms when they are subtler. But because the symptoms are less severe, physicians may be less likely to order testing to confirm PAH.

Younger patients make up one of the largest groups of uninsured Americans and therefore are less likely to seek early treatment.

Earlier diagnosis and treatment are vital, said Gregory Elliott, MD, chairman of the Department of Medicine at Intermountain Medical Center and another member of the research team.

"We have a lot more medications available to fight pulmonary arterial hypertension, but we can't use them all if we don't get to patients early enough in the course of the disease. If we can treat these patients sooner, we may find that we can improve survival," he said.

Researchers hope the study will give physicians more guidance in diagnosing pulmonary arterial hypertension.

"If a young person comes in complaining of shortness of breath, it’s alright to suspect something common. But if a patient is getting worse and not responding to treatment, it's time to look for something else," said Dr. Brown.

The study examined the medical records of 2,493 PAH patients from the national REVEAL registry (Registry to Evaluate Early and Long-term Pulmonary Arterial Hypertension Disease Management), including many of the 200 patients who are being treated at Intermountain Medical Center or University Hospital, the only hospitals in the Intermountain region capable of treating the complicated disease at an advanced stage.

Co-authors were from the University of Utah; University of California, San Francisco; University of Pennsylvania; the Mayo Clinic; Boston University Medical Center; and Baylor College of Medicine.

Intermountain Medical Center serves as the flagship facility for the Intermountain Healthcare system.

Jess C. Gomez | EurekAlert!
Further information:
http://intermountainhealthcare.org/Pages/home.aspx

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>