Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study identifies factors which predict alcohol use after liver transplantation

19.08.2010
Patients who receive a liver transplant due to alcoholic liver disease need to demonstrate periods of abstinence and often attend addiction treatment before transplantation.

However, alcohol use disorders can recur, as can other diseases requiring transplantation, and thus alcohol use after liver transplantation is not uncommon.

A new study published today in the American Journal of Transplantation reveals that those at highest risk to drink alcohol post transplant, especially in patterns that will damage their health, can be identified potentially preventing relapse.

Researchers led by Andrea DiMartini, MD, of the University of Pittsburgh Medical Center, collected data on alcohol consumption following liver transplantation for alcoholic liver disease in 208 patients transplanted between May 1998 to August 2004.

Alcohol relapse rates following liver transplantation are low, especially when compared to the general population. Of the 208 patients, 54% had no reported alcohol use post surgery.

However, among the remaining patients who did drink alcohol again, certain patterns emerged. Two patterns show early onset of alcohol use, one moderate and one accelerating to heavy use. These patterns show that for some patients, resumption occurs early following transplantation and recipients can quickly lose control over their drinking. For others, moderate to heavy alcohol use can begin years post surgery, showing that clinical monitoring for alcohol use should extend well beyond the first one to two years post-LTX.

The researchers found that the length of sobriety prior to surgery is the most powerful predictor of return to alcohol use, e.g. shorter sobriety conferring higher risk. Additionally, stresses immediately following surgery would increase the risk of alcohol use. Those more likely to drink were experiencing more problems overall, were more stressed, reported worse health, and had more pain and less energy.

"Our findings will aid clinicians in early monitoring and identification of patients at risk for alcohol use," DiMartini notes. "With improved methods to identify those at high risk, and effective treatments for alcohol use disorders, we can keep the relapse rates low and get patients into proper treatment before they injure their health."

This study is published in the American Journal of Transplantation. Media wishing to receive a PDF of this article may contact healthnews@wiley.com

Full citation: A. DiMartini, M.A. Dew, N. Day, M.G. Fitzgerald, B.L. Jones, M.E. deVera, and P. Fontes. Trajectories of Alcohol Consumption Following Liver Transplantation. American Journal of Transplantation 2010; 10: 1-8. DOI: 10.1111/j.1600-6143.2010.03232.x

About the Author: Andrea DiMartini, MD, is affiliated with the University of Pittsburgh Medical Center, Starzl Transplant Institute.

To arrange an interview with an author, please contact Dr. DiMartini's press office contact, Kristin Beaver, at beaverkc@upmc.edu

About the Journal

American Journal of Transplantation reflects the field and is an agent for advancing it through critical reviews and news features, consensus documents and guidelines. The journal is directed at scientists and clinicians in transplantation but also at those in other fields who wish to follow transplantation. The scope is the international discipline of transplantation. This includes organ and tissue donation and preservation; tissue injury, repair, inflammation, and aging; immune recognition, regulation, effector mechanisms, and opportunities for induction of tolerance; histocompatibility; drugs and pharmacology relevant to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses; transplant complications; xenotransplantation; and ethical and societal issues. The sciences includes relevant aspects of cell biology, medicine, surgery, pediatrics, and infectious diseases. The journal includes thoracic transplantation (heart, lung), abdominal transplantation (kidney, liver, pancreas, islets), transplantation of tissues and related topics.

About Wiley-Blackwell

Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit www.wileyblackwell.com or our new online platform, Wiley Online Library (wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.

Amy Molnar | EurekAlert!
Further information:
http://www.wiley.com

More articles from Studies and Analyses:

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>