The retrospective study, led by Christopher McPherson, MD, director of the division of surgical neuro-oncology at UC and a Mayfield Clinic neurosurgeon, was published online in May in the Journal of Neurosurgery. The abstract can be accessed at http://thejns.org/doi/abs/10.3171/2009.3.JNS081695.
The UC study compared the complication rates of stereotactic biopsies in functional, or “eloquent,” areas of the brain that were associated with language, vision, and mobility to areas that were not associated with critical functions. Eloquent areas included the brainstem, basal ganglia, corpus callosum, motor cortex, thalamus, and visual cortex. Complications were defined as the worsening of existing neurological deficits, seizures, brain hemorrhaging and death.
“Needle biopsies in eloquent areas have generally been acknowledged to be safe, because the needle causes only a small amount of disruption to the brain,” McPherson explains. “But until now, researchers had not actually documented that biopsies in eloquent areas were as safe as those in non-eloquent areas.”
To make that comparison, McPherson’s team studied records of 284 stereotactic needle biopsies performed by 19 Mayfield Clinic neurosurgeons between January 2000 and December 2006. In the 160 biopsies that involved eloquent areas of the brain, complications occurred in nine cases (5.6 percent of the total). In the 124 biopsies that involved non-eloquent areas, complications occurred in 10 cases (8.1 percent). The difference was not statistically significant.
Overall, 19 of the 284 patients, or 6.7 percent, suffered complications. Thirteen of those patients recovered completely or somewhat from their complications, while six (2.1 percent of the total number of patients biopsied) experienced permanent neurological decline.
“Diagnosing and treating brain tumors always carries risk,” McPherson says. “Within that context, the results of this large sampling of biopsies are encouraging overall and reinforce our belief that stereotactic biopsy is a valuable diagnostic tool. Stereotactic biopsy is a safe way for us to remove a tissue sample for the diagnosis of a brain tumor, even when the tumor is in a challenging and dangerous part of the brain.”
Additional co-authors of the study are Ronald Warnick, MD, director of the UC Brain Tumor Center and chairman of the Mayfield Clinic; James Leach, MD, associate professor of neuroradiology at UC and a neuroradiologist at Cincinnati Children’s Hospital Medical Center and the UC Neuroscience Institute; and Ellen Air, MD, PhD, a resident in the UC Department of Neurosurgery.
The Brain Tumor Center, under Warnick’s direction, treats hundreds of patients from the Greater Cincinnati region and beyond each year. The multidisciplinary center, which includes specialists in neurosurgery, radiology, radiation oncology, otolaryngology, internal medicine and physical medicine and rehabilitation, is committed to evidence-based medicine, compassionate care, research and the utilization of emerging therapies and technologies.
Cindy Starr | EurekAlert!
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
23.05.2018 | Life Sciences
23.05.2018 | Life Sciences
23.05.2018 | Physics and Astronomy