Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New study finds molecular mechanisms that control Rb2/p130 gene expression in lung cancer

28.02.2011
Despite innumerable studies on lung cancer, many aspects of the disease have yet to be understood, including the role played by the retinoblastoma-related protein Rb2/p130 in the evolution of the disease.

In a new study, researchers from the Sbarro Health Research Organization Center for Biotechnology Research (SHRO), a cancer, cardiovascular and diabetes research center located in the College of Science and Technology at Temple University in Philadelphia, PA, and at the University of Siena in Siena, Italy examined mechanisms that control Rb2/p130 gene expression in lung fibroblasts and characterize the effects of Rb2/p130 deregulation on the proliferative features of lung cancer cells. Most importantly, their findings reveal why the gene is expressed differently in small and nonsmall lung cancer cells.

The study was funded by SHRO and the Human Health Foundation, a nonprofit biomedical research organization in Terni, Italy. It was published in Molecular Cancer Research.

The new findings disclose the mechanism controlling Rb2/p130 gene expression in lung cells, and that involve two relatively new proteins, CCCTC-binding factor (CTCF) and BORIS (CTCF-paralogue).

"Our research shows that CTCF and BORIS directly regulate Rb2/p130 gene expression in lung cells," says Marcella Macaluso, Ph.D., one of the authors of the study. "We observed that in small lung cancer cells Rb2/p130 exhibits low expression levels, while in non- small lung cancer cells it is overexpressed compared to normal lung cells. However, until now, there were insufficient and conflicting data that did not allow us to precisely link the deregulated expression of Rb2/p130 in lung cancer cells with the genetic mutation of this gene. This study finally disclosed the mechanism and the players controlling Rb2/p130 expression, and these findings have the high potential to provide important information for understanding the proliferative and antiproliferative signals triggered by Rb2/p130."

Also, the research shows that Rb2/p130 is engaged in a complex network of interactions with DNA methyltransferases (DNMTs) and other proteins, including CTCF and BORIS, that are involved in the epigenetic control of chromatin organization and transcription. This complex network of proteins seems to regulate cellular senescence – or aging -- that is a potent anti-cancer mechanism.

"Our studies may provide new insights into the molecular pathways that that are active and correlated to Rb2/p130 expression, new biomarkers for an early diagnosis of lung cancer and/or predictive factors to determine the effect on tumor treatments and insights into the development of therapies based upon clinical modulation of Rb2/p130, CTCF and/or BORIS expression," says Dr. Macaluso.

Future studies are planned to study and decisively dissect the multiple functions of Rb2/p130 in non-small and small cell lung cancer.

Sbarro Health Research Organization Center for Biotechnology Research (www.shro.org) funds the Sbarro Institute for Cancer Research and Molecular Medicine, a leading nonprofit research center for cancer, diabetes, and cardiovascular disease. Based in Philadelphia, Pennsylvania on the campus of Temple University and the University of Siena in Italy, our programs train young scientists from around the globe.

Ilene Raymond Rush | EurekAlert!
Further information:
http://www.shro.org

More articles from Studies and Analyses:

nachricht The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>