Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study finds increased presence, severity of coronary artery plaques in HIV-infected men

08.01.2010
Inflammation, other immune-system factors may increase cardiovascular risk

A Massachusetts General Hospital (MGH) study has found that relatively young men with longstanding HIV infection and minimal cardiac risk factors had significantly more coronary atherosclerotic plaques – some involving serious arterial blockage – than did uninfected men with similar cardiovascular risk. The investigation appearing in the January 2010 issue of the journal AIDS is the first to use CT angiography to identify coronary artery plaques in HIV-infected participants.

"We were particularly surprised to find that several of the HIV patients – none of whom had symptoms of heart disease – had obstructive coronary artery disease, which was found in none of the controls," says Janet Lo, MD, of the Program in Nutritional Metabolism in the MGH Department of Medicine, who led the study. "It appears that both traditional and nontraditional risk factors are contributing to atherosclerotic disease in HIV-infected patients."

Several previous studies have found increased incidence of heart attacks and other cardiovascular events among HIV-infected patients, but it has not been clear whether that risk was attributable to recognized risk factors, such as elevated cholesterol and smoking, or to HIV-related immune system factors. The current study enrolled 110 men – 78 with HIV infection and 32 uninfected controls – without symptoms of cardiovascular disease. Participants ranged in age from 18 to 55, and both groups had low levels of traditional cardiovascular risk factors. The HIV-positive participants had longstanding infection, were generally healthy, and the great majority were receiving antiretroviral therapy.

After a detailed interview and physician examination, participants received both a standard cardiac CT scan using a 64-slice multidetector CT scanner and CT angiography. While the cardiac CT scan identifies calcium deposits in coronary arteries, CT angiography can also find non-calcified arterial plaques. The standard scans showed that the HIV-infected participants had levels of coronary calcium that, based on previous studies, would be expected in men who were six years older. The CT angiography revealed coronary atherosclerosis in 59 percent of the HIV-infected patients, compared with only 34 percent of controls. Five of the HIV-positive participants had critical coronary stenosis – 70 percent or greater narrowing of one or more arterial segments – something seen in none of the controls. Those participants were all referred to cardiologists for further evaluation and treatment.

"Our findings highlight the need to address reduction of cardiac risk factors early in the course of HIV disease and for caregivers to consider that even asymptomatic patients with longstanding HIV disease and minimal cardiac risk factors may have significant coronary artery disease," says Lo, who is an instructor in Medicine at Harvard Medical School. "We also found interesting associations between the degree of atherosclerosis and how long participants had been infected with HIV and with several inflammatory and immune factors. Future studies are needed to clarify the role of these nontraditional risk factors and find the best prevention and treatment strategies for these patients."

Steven Grinspoon, MD, director of the MGH Program in Nutritional Metabolism, is senior author of the AIDS report. Additional co-authors are Jeffrey Wei, Program in Nutritional Metabolism; and Sunny Abbara, MD, Leon Shturman, Anand Soni, Jose Rocha-Filho and Khurram Nasir, MGH Radiology. The study was supported by grants from the National Institutes of Health and Bristol Myers Squibb, Inc.

Massachusetts General Hospital, established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $600 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, systems biology, transplantation biology and photomedicine.

Sue McGreevey | EurekAlert!
Further information:
http://www.mgh.harvard.edu

More articles from Studies and Analyses:

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

nachricht Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Gold shines through properties of nano biosensors

17.08.2017 | Physics and Astronomy

Greenland ice flow likely to speed up: New data assert glaciers move over sediment, which gets more slippery as it gets wetter

17.08.2017 | Earth Sciences

Mars 2020 mission to use smart methods to seek signs of past life

17.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>