Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study finds important risk factors for death and transplantation in children with heart muscle disease

26.07.2011
WHAT: Researchers have identified important risk factors for death and transplantation in children with dilated cardiomyopathy (heart muscle disease), according to results from a study supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health.

Using these risk factors, physicians may be able to better identify children who will or will not benefit from life-saving transplantation surgery; the current criteria for receiving a transplant sometimes miss children who may benefit.

If the findings of the report are successfully used nationwide, the indications for heart transplantation may be broadened giving more children access to this life-prolonging therapy.

“Competing risks for death and cardiac transplantation in children with dilated cardiomyopathy: results from the Pediatric Cardiomyopathy Registry,” was published online today in Circulation, the journal of the American Heart Association.

Risk factors identified for either death, transplantation, or both include presence of congestive heart failure, echocardiographic evidence of more severe disease, increased age, dilation of the left ventricle, and height. Short stature increased the risk of death but not transplantation. Researchers also found that the causes of dilated cardiomyopathy strongly affected which risk factors were predictive of death and/or transplantation. This suggests that establishing the cause of disease as soon as possible is critically important.

This population-based study used data from the Pediatric Cardiomyopathy Registry (PCMR). From 1990 to 2007, the PCMR, led by the University of Miami Leonard M. Miller School of Medicine, enrolled 1,731 children (18 years of age or younger) diagnosed with pediatric dilated cardiomyopathy, the most common heart muscle disease. Dilated cardiomyopathy can lead to heart valve problems, arrhythmias (irregular heartbeats), blood clots in the heart, and even heart failure.

For 57 percent of children who suffer from cardiomyopathy, the cause of the disease is unknown. The nationwide registry was established to collect and organize data on the condition, which will help determine the causes of the disease and lead to new and better treatments.

Learn more about the Pediatric Cardiomyopathy Registry at: http://www.pcmregistry.org/ or http://clinicaltrials.gov/ct2/show/NCT00005391
WHO: Jonathan R. Kaltman, M.D., medical officer in the Heart Development and Structural Diseases Branch in the Division of Cardiovascular Sciences at the NHLBI, and program officer of the NHLBI Pediatric Cardiomyopathy Registry. Dr. Kaltman’s complete bio can be viewed online at:

http://public.nhlbi.nih.gov/Newsroom/home/ShowBio.aspx?PID=2788

CONTACT: For more information or to schedule an interview with Dr. Kaltman, contact the NHLBI Office of Communications at 301-496-4236 or nhlbi_news@nhlbi.nih.gov. To schedule an interview with Steven E. Lipshultz, M.D., principal investigator of the study and professor and chairman of the Department of Pediatrics at University of Miami Miller School of Medicine; or with Jorge A. Alvarez, M.D., Ph.D., study investigator, University of Miami Miller School of Medicine, please contact Jeanne Krull at the University of Miami at 305-243-4853 or jkrull@miami.edu.

Part of the National Institutes of Health, the National Heart, Lung, and Blood Institute (NHLBI) plans, conducts, and supports research related to the causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, and blood diseases; and sleep disorders. The Institute also administers national health education campaigns on women and heart disease, healthy weight for children, and other topics. NHLBI press releases and other materials are available online at www.nhlbi.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

| EurekAlert!
Further information:
http://www.nih.gov

More articles from Studies and Analyses:

nachricht Amputees can learn to control a robotic arm with their minds
28.11.2017 | University of Chicago Medical Center

nachricht The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>