The American College of Obstetricians and Gynecologists recommends that fetal pulmonary maturity be documented for scheduled deliveries occurring prior to 39 weeks of gestation in order to prevent neonatal respiratory problems.
"We wanted to do the study because recent evidence suggests that deliveries prior to 39 weeks may result in increased neonatal morbidity," said Yu Ming Victor Fang, M.D., one of the study's authors. "We wanted to examine whether neonates who were delivered at between 36 to 38 completed weeks with confirmed fetal pulmonary maturity would be at increased risk for neonatal morbidities when compared to those that were delivered at 39 weeks or greater."
To compare neonatal outcomes, the team looked at mothers who had positive fetal lung maturity tests at between 36 to 38 completed weeks. They compared the neonatal outcomes from these scheduled deliveries prior to 39 weeks with known fetal lung maturity to the outcomes from scheduled deliveries at 39 weeks to 41 completed weeks.
The study was a retrospective cohort study from a single institution over a 12 year period. Neonatal outcomes of women who were delivered following documented fetal pulmonary maturity at 36, 37, and 38 weeks were compared to women undergoing a scheduled delivery at 39, 40, and 41 weeks. A lamellar body count of ¡Ý36,000, lecitin/sphingomyelin (L/S) ratio >2.0, or a phosphotidyglycerol (PG) of 0.3 were considered mature. Neonatal outcomes examined included: neonatal intensive care unit (NICU) admission, length of stay (LOS) in the NICU, total neonatal respiratory morbidity (Tot resp morbid), cases of respiratory distress syndrome (RDS), transient tachypnea of the newborn (TTN), other respiratory morbidity (other resp morbid), neonates requiring mechanical ventilation (Vent), proven sepsis (Sepsis), hypoglycemia, and neonatal deaths. Fetuses with major congenital anomalies were excluded. Neonatal outcomes between the two groups were compared using the chi square test.
The study concluded that despite fetal pulmonary maturity, deliveries between 36 0/7 to 38 6/7 weeks are associated with significantly increased neonatal morbidity.
"Patients need to be counseled carefully if they choose to have a scheduled delivery prior to 39 weeks," said Dr. Fang. "Even if tests indicate that their baby's lungs are mature, delivery prior to 39 weeks is not without risks."
For interviews or a copy of the abstract please contact Vicki Bendure at Vicki@bendurepr.com, or 202-374-9259.
The Society for Maternal-Fetal Medicine (est. 1977) is a non-profit membership group for obstetricians/gynecologists who have additional formal education and training in maternal-fetal medicine. The society is devoted to reducing high-risk pregnancy complications by providing continuing education to its 2,000 members on the latest pregnancy assessment and treatment methods. It also serves as an advocate for improving public policy, and expanding research funding and opportunities for maternal-fetal medicine. The group hosts an annual scientific meeting in which new ideas and research in the area of maternal-fetal medicine are unveiled and discussed.
Vicki Bendure | EurekAlert!
Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland
Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy