Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study finds community counseling reduced the prevalence of TB on a budget

31.10.2011
The results of a large-scale community-randomized trial presented at the 42nd World Conference on Lung Health in Lille, France today show that the Zambia-South Africa TB and AIDS Reduction (ZAMSTAR) project reduced the prevalence of tuberculosis by 22%.

The intervention lasted for three years (2006 - 2009), during which the ZAMSTAR communities (in conjunction with the district and provincial health services) received support to improve TB & HIV care and service integration, including improved and community-wide TB testing and TB & HIV counselling within communities and households to facilitate prompt diagnosis and treatment.

Taking place in 24 communities across Zambia and in the Western Cape Province of South Africa, the ZAMBART project focused on finding ways to stop the transmission of TB in communities with a high burden of both TB and HIV. A total of roughly 1m individuals were involved in the ZAMSTAR interventions at a cost of less than one US dollar per person per year.

"In the era of HIV, this is the first community-randomised trial of a public health intervention to be shown to have an impact on the epidemiology of TB at community-level," said Dr. Peter Godfrey-Faussett, one of three ZAMSTAR Principal Investigators and Professor of Infectious Diseases and International Health at London School of Hygiene and Tropical Medicine (LSHTM).

ZAMSTAR employed many individuals who lived in the trial communities and who were involved in activities such as street dramas, songs and dances to encourage people to submit sputum samples for TB testing. Around 25% of all the most infectious cases that were diagnosed in the communities were found because thanks to this intervention.

"In these communities, TB and HIV affect the entire household, so you need to involve not only the TB patient but his or her entire family. If adults are not diagnosed and treated, they can infect children" said Dr Helen Ayles, ZAMSTAR Principal Investigator and Project Coordinator for ZAMBART." In addition to the reduced prevalence rate, in the communities that received household counselling children were half as likely to become infected with TB thanks to the intervention."

"ZAMSTAR really was an amazing partnership between researchers, communities and health services and the interventions were both well-received and appreciated by the communities in which we worked," said Dr. Nulda Beyers, ZAMSTAR Principal Investigator and Director of the DTTC.

In addition, ZAMSTAR leaves a legacy of hundreds of research assistants, counsellors and clinic staff who were trained during the three-year project and who now have a greater understanding not only of TB and HIV but also of community-based research, ethics and international cooperation. The work of the ZAMSTAR study has the potential to translate into real reductions in the overall burden of TB in high-burden areas.

The ZAMSTAR study was carried out by a consortium of three institutions, Zambia AIDS Related TB (ZAMBART) Project, Desmond Tutu TB Centre (DTTC) at the Stellenbosch University and the London School of Hygiene and Tropical Medicine (LSHTM), as one of three large studies within the Consortium to Respond Effectively to the AIDS and TB Epidemics (CREATE). Funding for this $27 million study came from the Bill and Melinda Gates Foundation.

About The Consortium to Respond Effectively to the AIDS/TB Epidemic:

Funded by a grant from the Bill and Melinda Gates Foundation in 2002, CREATE – the Consortium to Respond Effectively to the AIDS/TB Epidemic - is a consortium of leading experts in TB and HIV who design novel public health interventions to reduce the burden of HIV-related TB at the population level.

The Consortium is led by the Johns Hopkins University Center for Tuberculosis Research, in Maryland, U.S.A., and includes the following partners:

Aurum Institute for Health Research - Johannesburg, South Africa

Desmond Tutu Centre at Stellenbosch University - Tygerberg, South Africa

Municipal Health Secretariat of Rio de Janeiro - Rio de Janeiro, Brazil

London School of Hygiene and Tropical Medicine - London, England

ZAMBART Project - Lusaka, Zambia

Stop TB Partnership, WHO

Led by Dr. Richard Chaisson, CREATE hopes to transform global policies for TB/HIV through evidence-based advocacy. http://www.tbhiv-create.org/

About London School of Hygiene and Tropical Medicine:

The London School of Hygiene & Tropical Medicine (LSHTM) is a renowned research-led postgraduate institution of public health and global health. Its mission is to improve health in the UK and worldwide through the pursuit of excellence in research, postgraduate teaching and advanced training in national and international public health and tropical medicine, and through informing policy and practice in these areas. Part of the University of London, the School is the largest institution of its kind in Europe with a remarkable depth and breadth of expertise encompassing many disciplines associated with public health. http://www.lshtm.ac.uk

About Desmond Tutu TB Centre:

The Desmond Tutu TB Centre is an academic research centre of the Department of Paediatrics and Child Health, Faculty of Health Sciences. It has as its mission the improvement of the health of vulnerable groups through influencing policy based on new knowledge created by research focusing on health, mainly TB and HIV. To achieve this, the Centre works closely with the South African Department of Health and the local communities. It provides training to academic and health services staff, builds capacity in the University and the Department of Health, provides service to communities and advocates for TB and health. Himself a former TB sufferer, Archbishop Desmond Tutu champions tuberculosis research and care. He is also the patron of the on-campus Tygerberg Children's Hospital. http://www.sun.ac.za/tb

About ZAMBART Project:

The Zambia AIDS Related Tuberculosis (ZAMBART) Project has conducted research into the dual TB/HIV epidemic for 20 years in Zambia. In 2004 ZAMBART established itself as a Zambian NGO from a collaboration between the University of Zambia School of Medicine and the London School of Hygiene and Tropical Medicine, and it is now based in the University of Zambia School of Medicine Campus. ZAMBART now collaborates closely with government, non-governmental and academic institutions within Zambia, Africa and the rest of the world. ZAMBART is also committed to increasing Zambian research capacity. http://www.zambart.org

Contact:
Justin O'Brien,
Policy, Advocacy and Communications Manager
ZAMBART Project
4407825491168
justin@zambart.org.zm

Justin O’Brien | EurekAlert!
Further information:
http://www.zambart.org

More articles from Studies and Analyses:

nachricht Do microplastics harbour additional risks by colonization with harmful bacteria?
05.04.2018 | Leibniz-Institut für Ostseeforschung Warnemünde

nachricht Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

Im Focus: The Future of Ultrafast Solid-State Physics

In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.

Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Diamond-like carbon is formed differently to what was believed -- machine learning enables development of new model

19.04.2018 | Materials Sciences

Electromagnetic wizardry: Wireless power transfer enhanced by backward signal

19.04.2018 | Physics and Astronomy

Ultrafast electron oscillation and dephasing monitored by attosecond light source

19.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>