The study will appear in the June issue of the journal Environmental Toxicology and Chemistry and is the first to test multiple PBDE mixtures for changes in behavior, physical malformations and mortality on zebra fish.
PBDEs are found in many common household products from blankets to couches to food wrappers. Lab tests have shown that PBDEs have been found in human breast milk and cord blood. Previous studies have showed children with high levels of PBDEs in their umbilical cord at birth scored lower on tests between one and six years of age. In 2006, the state of California started prohibiting the use of PBDEs.
The family of PBDEs consists of more than 200 possible substances, which are called congeners. Congeners are considered low if they average between 1 to 5 bromine atoms per molecule.
The Baylor researchers tested six PBDE congeners for developmental effects on embryonic zebra fish. Changes in behavior, physical malformations and mortality were recorded daily for seven days.
The results showed:
• Lower brominated congeners were more toxic than higher brominated congeners.
• Embryos were most sensitive to two particular types of PBDE exposures, the two lowest brominated congeners of the six tested. Both induced a curved body axis and eventually death.
• In all, four of the six congeners tested caused developmental malformations, such as a curved body axis and pulmonary edema. Five of the six caused alterations in behaviors, such as decreased swimming rates and increased spontaneous movement in the embryo.
“While most PBDEs have either been banned or phased out throughout the world, it may be more beneficial to identify congeners of concern rather than replacing these compounds with chemicals of unknown biological interactions,” said Dr. Erica Bruce, assistant professor of environmental science at Baylor who is an expert in environmental chemicals and their effects on public health. “Alterations in early behavior may potentially be due to disruption of thyroid hormones. Thyroid hormones play a vital role in the development of the cholinergic system and this study gives insight into biological interaction within a few hours of exposure. The observed hyperactivity may be due to overstimulation of the cholinergic system,” Bruce said.
Matt Pene | Newswise Science News
Do microplastics harbour additional risks by colonization with harmful bacteria?
05.04.2018 | Leibniz-Institut für Ostseeforschung Warnemünde
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.
Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
19.04.2018 | Materials Sciences
19.04.2018 | Physics and Astronomy
19.04.2018 | Physics and Astronomy