Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study confirms how the body regulates high levels of CO2 in the blood

12.06.2014

In experiments published in the journal Experimental Physiology, Brazilian researchers have confirmed the importance of a specific group of neurons found in the retrotrapezoid nucleus

In a recently published study in the journal Experimental Physiology, Brazilian researchers have confirmed the importance of a specific group of neurons found in a region of the brain known as the retrotrapezoid nucleus (RTN) in detecting changes in carbon dioxide (CO2) levels and in modulating the activity of the neuronal groups that control respiratory activity.

Scientists from the Biomedical Sciences Institute of the University of São Paulo (USP) and the School of Dentistry at the São Paulo State University (Unesp) participated in the study.

"CO2 is important for regulating the acid-base balance of the blood. When the concentration of this gas becomes higher than normal, the blood tends to become more acidic, which promotes the activation of specialized sensors called chemoreceptors," said Eduardo Colombari, professor at the School of Dentistry at Unesp.

"Some of these chemoreceptors are located in the central nervous system; more precisely, on the ventrolateral surface of the medulla oblongata [the region of the brain responsible for neurovegetative control that forms the interface between the spinal cord and the mesencephalon] in the RTN," he explained.

According to Colombari, the neurons in this region express a specific marker that allows them to be identified. This marker consists of a transcription factor called Phox2b, which is involved in the cell differentiation of autonomic and respiratory neurons, that communicate with other neural groups responsible for controlling respiratory activity in order to keep CO2 levels within the physiological range.

Previous studies in the scientific literature, said Colombari, have suggested that various neuronal groups, such as the nucleus of the solitary tract, the raphe nuclei (which secrete serotonin), and the pontine and hypothalamic areas, were involved in the control of chemoreception (in this case, the detection and modulation of CO2 levels).

The group's work has demonstrated, however, that the respiratory changes caused by the increase in CO2 levels are compromised during the occurrence of selective destruction of the RTN neurons that express Phox2b.

The researcher further explained that the work illustrated how a small region of the brain contains neurons with a classic biochemical signature (Phox2b) which are involved in detecting and maintaining adequate levels of CO2, thus allowing the maintenance of homeostasis.

According to Colombari, advances in understanding the mechanisms involved in the perception of CO2 levels in the central nervous system could help prevent cases of sudden death in infants and adults in the future.

Samuel Antenor | Eurek Alert!
Further information:
http://www.fapesp.br/

Further reports about: Amparo Biomedical CO2 Dentistry Homeostasis Physiology activity biochemical blood carbon dioxide

More articles from Studies and Analyses:

nachricht Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland

nachricht Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>