Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Studies Examine Links Between XMRV and Human Disease

13.10.2010
Evidence Supports Possible Links with Cancer but not Chronic Fatigue Syndrome

Xenotropic murine leukemia virus¨Crelated virus (XMRV) has been the subject of many studies since its discovery in 2006, but conflicting reports have created an unclear picture of XMRV¡¯s role in human disease.

In three recent studies published in the November 15 issue of The Journal of Infectious Diseases, now available online, the evidence supports a possible link between XMRV and prostate cancer but not other links involving chronic fatigue syndrome, HIV infection, or hepatitis C virus (HCV) infection. (Please see below for links to these articles online.)

In one of the studies, led by Athe Tsibris, MD, investigators from Boston determined XMRV prevalence in a variety of North American clinic populations. The study included healthy subjects, participants with CFS, and participants with chronic immune activation or suppression.

Study samples were obtained from adult patients presenting to outpatient clinics or from pre-existing samples at Brigham and Women¡¯s Hospital, Massachusetts General Hospital, and Dana-Farber Cancer Institute. Researchers did not detect XMRV in any of the 293 patients tested, and the investigators did not find an association between XMRV and patients with CFS, chronic immune suppression, or medical conditions associated with chronic immune activation.

Researchers were surprised that they did not detect XMRV in any of the study participants, despite the high prevalence previously reported. A previous study in the United States found evidence of XMRV DNA in 67 percent of subjects with chronic fatigue syndrome (CFS), compared to 3.7 percent of healthy controls. Subsequent studies in Europe, however, were unable to demonstrate the presence of XMRV in CFS subjects or healthy controls.

¡°The findings suggest that in the population we tested, XMRV is not associated with chronic fatigue syndrome and suggests that differences in PCR technique from study to study do not explain the disparate results seen in XMRV studies of chronic fatigue syndrome,¡± Dr. Tsibris said.

A second study, led by Eleanor Barnes, MD, aimed to detect XMRV in patients with HIV-1 or hepatitis C virus (HCV) infection in the United Kingdom and Switzerland. Because the route of transmission for XMRV has not been established, Dr. Barnes and the researchers tested individuals who were at high risk for contracting blood-borne or sexually transmitted infections. Investigators tested plasma and peripheral blood mononuclear cells to determine if these patients were at risk for XMRV infection.

Investigators did not find XMRV in any of the 230 patients with HIV or HCV infections. According to the researchers, ¡°This study provides the first evidence that if XMRV is a human pathogen, it is not enriched in the blood of patients with HIV or HCV, and by implication it is unlikely to be spread though sexual or blood-borne routes in the UK and Western Europe.¡± In light of these findings, Dr. Barnes noted that further studies are necessary to explore potential transmission routes and determine which members of the population may be at risk.

The possible association between XMRV and human prostate cancer has also been questioned by conflicting studies. Jason T. Kimata, PhD, and investigators from the Baylor College of Medicine looked for XMRV in 144 patients with prostate cancer from the southern United States. Researchers were able to detect XMRV in 22 percent of men with prostate cancer. XMRV was present in both normal and tumor tissue of men with prostate cancer. According to the authors, this suggests that the virus may not specifically target cancer cells for infection and that infection may precede cancer. Dr. Kimata emphasized the need to ¡°continue discussions about XMRV detection assay methodologies, so that discrepancies in the findings of different research groups can be addressed.¡±

In an accompanying editorial, Frank Maldarelli, MD, PhD, and Mary Kearney, PhD, of the National Cancer Institute, pointed out that differences among various studies may be related to a variety of factors, including geography, patient selection, and detection techniques. They noted that these three new studies highlight the need for standardization of detection assays, prospective epidemiological surveys, and sharing of reagents and samples among investigators. Only when this is done in a rigorous fashion will it become clear what role XMRV or related viruses have in human disease.

Fast Facts:

Investigators from Boston did not find an association between XMRV and patients with CFS, chronic immune suppression, or medical conditions associated with chronic immune activation, in a study in the November 15 issue of The Journal of Infectious Diseases.

In a second study in the same issue, European researchers did not find XMRV in any of 230 patients infected with HIV or HCV, suggesting that XMRV is unlikely to be transmitted by blood or sexual exposure.

Researchers at Baylor College of Medicine detected XMRV in 22 percent of men with prostate cancer, in both tumor and normal tissues, according to a third study in the issue.

The studies highlight the need for standardization of XMRV detection assays, prospective epidemiologic surveys of its prevalence, and sharing of reagents and samples among investigators to clarify what role XMRV or related viruses play in human disease.

Note: The three studies and the accompanying editorial are available online:

¡°Xenotropic Murine Leukemia Virus¨CRelated Virus Prevalence in Patients with Chronic Fatigue Syndrome or Chronic Immunomodulatory Conditions¡± http://www.journals.uchicago.edu/doi/abs/10.1086/657168

¡°Failure to Detect Xenotropic Murine Leukemia Virus¨CRelated Virus in Blood of Individuals at High Risk of Blood©Borne Viral Infections¡±

http://www.journals.uchicago.edu/doi/abs/10.1086/657167

¡°Detection of Xenotropic Murine Leukemia Virus¨CRelated Virus in Normal and Tumor Tissue of Patients from the Southern United States with Prostate Cancer Is Dependent on Specific Polymerase Chain Reaction Conditions¡±

http://www.journals.uchicago.edu/doi/abs/10.1086/656146

¡°Current Status of Xenotropic Murine Leukemia Virus¨CRelated Retrovirus in Chronic Fatigue Syndrome and Prostate Cancer: Reach for a Scorecard, Not a Prescription Pad¡±

http://www.journals.uchicago.edu/doi/abs/10.1086/657169

Founded in 1904, The Journal of Infectious Diseases is the premier publication in the Western Hemisphere for original research on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune mechanisms. Articles in JID include research results from microbiology, immunology, epidemiology, and related disciplines. It is published under the auspices of the Infectious Diseases Society of America (IDSA). Based in Arlington, Va., IDSA is a professional society representing nearly 8,000 physicians and scientists who specialize in infectious diseases. Nested within the IDSA, the HIV Medicine Association (HIVMA) is the professional home for more than 2,600 physicians, scientists and other health care professionals dedicated to the field of HIV/AIDS. HIVMA promotes quality in HIV care and advocates policies that ensure a comprehensive and humane response to the AIDS pandemic informed by science and social justice.

John Heys | EurekAlert!
Further information:
http://www.idsociety.org

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D

08.12.2016 | Materials Sciences

Decoding cement's shape promises greener concrete

08.12.2016 | Materials Sciences

Will Earth still exist 5 billion years from now?

08.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>