Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Studies Examine Links Between XMRV and Human Disease

13.10.2010
Evidence Supports Possible Links with Cancer but not Chronic Fatigue Syndrome

Xenotropic murine leukemia virus¨Crelated virus (XMRV) has been the subject of many studies since its discovery in 2006, but conflicting reports have created an unclear picture of XMRV¡¯s role in human disease.

In three recent studies published in the November 15 issue of The Journal of Infectious Diseases, now available online, the evidence supports a possible link between XMRV and prostate cancer but not other links involving chronic fatigue syndrome, HIV infection, or hepatitis C virus (HCV) infection. (Please see below for links to these articles online.)

In one of the studies, led by Athe Tsibris, MD, investigators from Boston determined XMRV prevalence in a variety of North American clinic populations. The study included healthy subjects, participants with CFS, and participants with chronic immune activation or suppression.

Study samples were obtained from adult patients presenting to outpatient clinics or from pre-existing samples at Brigham and Women¡¯s Hospital, Massachusetts General Hospital, and Dana-Farber Cancer Institute. Researchers did not detect XMRV in any of the 293 patients tested, and the investigators did not find an association between XMRV and patients with CFS, chronic immune suppression, or medical conditions associated with chronic immune activation.

Researchers were surprised that they did not detect XMRV in any of the study participants, despite the high prevalence previously reported. A previous study in the United States found evidence of XMRV DNA in 67 percent of subjects with chronic fatigue syndrome (CFS), compared to 3.7 percent of healthy controls. Subsequent studies in Europe, however, were unable to demonstrate the presence of XMRV in CFS subjects or healthy controls.

¡°The findings suggest that in the population we tested, XMRV is not associated with chronic fatigue syndrome and suggests that differences in PCR technique from study to study do not explain the disparate results seen in XMRV studies of chronic fatigue syndrome,¡± Dr. Tsibris said.

A second study, led by Eleanor Barnes, MD, aimed to detect XMRV in patients with HIV-1 or hepatitis C virus (HCV) infection in the United Kingdom and Switzerland. Because the route of transmission for XMRV has not been established, Dr. Barnes and the researchers tested individuals who were at high risk for contracting blood-borne or sexually transmitted infections. Investigators tested plasma and peripheral blood mononuclear cells to determine if these patients were at risk for XMRV infection.

Investigators did not find XMRV in any of the 230 patients with HIV or HCV infections. According to the researchers, ¡°This study provides the first evidence that if XMRV is a human pathogen, it is not enriched in the blood of patients with HIV or HCV, and by implication it is unlikely to be spread though sexual or blood-borne routes in the UK and Western Europe.¡± In light of these findings, Dr. Barnes noted that further studies are necessary to explore potential transmission routes and determine which members of the population may be at risk.

The possible association between XMRV and human prostate cancer has also been questioned by conflicting studies. Jason T. Kimata, PhD, and investigators from the Baylor College of Medicine looked for XMRV in 144 patients with prostate cancer from the southern United States. Researchers were able to detect XMRV in 22 percent of men with prostate cancer. XMRV was present in both normal and tumor tissue of men with prostate cancer. According to the authors, this suggests that the virus may not specifically target cancer cells for infection and that infection may precede cancer. Dr. Kimata emphasized the need to ¡°continue discussions about XMRV detection assay methodologies, so that discrepancies in the findings of different research groups can be addressed.¡±

In an accompanying editorial, Frank Maldarelli, MD, PhD, and Mary Kearney, PhD, of the National Cancer Institute, pointed out that differences among various studies may be related to a variety of factors, including geography, patient selection, and detection techniques. They noted that these three new studies highlight the need for standardization of detection assays, prospective epidemiological surveys, and sharing of reagents and samples among investigators. Only when this is done in a rigorous fashion will it become clear what role XMRV or related viruses have in human disease.

Fast Facts:

Investigators from Boston did not find an association between XMRV and patients with CFS, chronic immune suppression, or medical conditions associated with chronic immune activation, in a study in the November 15 issue of The Journal of Infectious Diseases.

In a second study in the same issue, European researchers did not find XMRV in any of 230 patients infected with HIV or HCV, suggesting that XMRV is unlikely to be transmitted by blood or sexual exposure.

Researchers at Baylor College of Medicine detected XMRV in 22 percent of men with prostate cancer, in both tumor and normal tissues, according to a third study in the issue.

The studies highlight the need for standardization of XMRV detection assays, prospective epidemiologic surveys of its prevalence, and sharing of reagents and samples among investigators to clarify what role XMRV or related viruses play in human disease.

Note: The three studies and the accompanying editorial are available online:

¡°Xenotropic Murine Leukemia Virus¨CRelated Virus Prevalence in Patients with Chronic Fatigue Syndrome or Chronic Immunomodulatory Conditions¡± http://www.journals.uchicago.edu/doi/abs/10.1086/657168

¡°Failure to Detect Xenotropic Murine Leukemia Virus¨CRelated Virus in Blood of Individuals at High Risk of Blood©Borne Viral Infections¡±

http://www.journals.uchicago.edu/doi/abs/10.1086/657167

¡°Detection of Xenotropic Murine Leukemia Virus¨CRelated Virus in Normal and Tumor Tissue of Patients from the Southern United States with Prostate Cancer Is Dependent on Specific Polymerase Chain Reaction Conditions¡±

http://www.journals.uchicago.edu/doi/abs/10.1086/656146

¡°Current Status of Xenotropic Murine Leukemia Virus¨CRelated Retrovirus in Chronic Fatigue Syndrome and Prostate Cancer: Reach for a Scorecard, Not a Prescription Pad¡±

http://www.journals.uchicago.edu/doi/abs/10.1086/657169

Founded in 1904, The Journal of Infectious Diseases is the premier publication in the Western Hemisphere for original research on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune mechanisms. Articles in JID include research results from microbiology, immunology, epidemiology, and related disciplines. It is published under the auspices of the Infectious Diseases Society of America (IDSA). Based in Arlington, Va., IDSA is a professional society representing nearly 8,000 physicians and scientists who specialize in infectious diseases. Nested within the IDSA, the HIV Medicine Association (HIVMA) is the professional home for more than 2,600 physicians, scientists and other health care professionals dedicated to the field of HIV/AIDS. HIVMA promotes quality in HIV care and advocates policies that ensure a comprehensive and humane response to the AIDS pandemic informed by science and social justice.

John Heys | EurekAlert!
Further information:
http://www.idsociety.org

More articles from Studies and Analyses:

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

Im Focus: New nanomaterial can extract hydrogen fuel from seawater

Hybrid material converts more sunlight and can weather seawater's harsh conditions

It's possible to produce hydrogen to power fuel cells by extracting the gas from seawater, but the electricity required to do it makes the process costly. UCF...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Study suggests oysters offer hot spot for reducing nutrient pollution

17.10.2017 | Life Sciences

Breaking: the first light from two neutron stars merging

17.10.2017 | Physics and Astronomy

World first for reading digitally encoded synthetic molecules

17.10.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>