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Your Stroke Risk Profile May Also Help Predict Your Risk of Memory Problems

A new study shows a person’s stroke risk profile, which includes high blood pressure, smoking, and diabetes, may also be helpful in predicting whether a person will develop memory and thinking problems later in the life. The research is published in the November 8, 2011, issue of Neurology®, the medical journal of the American Academy of Neurology.

Researchers in the REGARDS study followed 23,752 people with an average age of 64 who were free of stroke and cognitive problems at the start of the study. Participants underwent a Framingham Stroke Risk Profile, which is used to determine a person’s risk of stroke by measuring their age, blood pressure, education level, history of heart disease, smoking and diabetes status, and whether they have left ventricular hypertrophy (a thickening of the heart muscle) and an abnormal heart rhythm.

After an average of four years of follow-up, 1,907 people had developed memory and thinking problems.

The study found the higher a person’s score on the Stroke Risk Profile, the greater the chance of developing cognitive problems four years later. Fifteen percent of people who scored among the highest 25 percent on the Stroke Risk Profile test (greater than 11.99 points) had cognitive problems compared to three percent of those who scored among the bottom 25 percent with a score below 3.4 points.

“Overall, it appears that the total Stroke Risk Profile score, while initially created to predict stroke, is also useful in determining the risk of cognitive problems,” said study author Frederick Unverzagt, PhD, of Indiana University School of Medicine in Indianapolis.

The study found older age and the presence of thickening in the heart muscle, which is a result of long-term high blood pressure, were the only Stroke Risk Profile factors independently associated with future cognitive problems. This association remained even after controlling for age, sex, race, where a person lived and education. In addition, the study also found high systolic blood pressure was related to cognitive problems in people without a thickening of the heart muscle.

“Our findings suggest that elevated blood pressure and thickening of the heart muscle may provide a simple way for doctors to identify people at risk for memory and thinking problems,” said Unverzagt. “Increased focus on preventing and treating high blood pressure may be needed to preserve cognitive health.”

The REasons for Geographic and Racial Differences in Stroke (REGARDS) study was supported by the National Institute of Neurological Disorders and Stroke, of the National Institutes of Health, Department of Health and Human Services.

The American Academy of Neurology, an association of more than 24,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.

For more information about the American Academy of Neurology, visit

Rachel L. Seroka | American Academy of Neurology
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