That such stress during a mother’s pregnancy can cause developmental and emotional problems for offspring has long been observed by behavioral and biological researchers, but the objective measuring and timing of that stress and its results are difficult to prove objectively in humans, since the evidence is based to a large extent on anecdotal recollections and is also strongly influenced by genetic and other factors.
One researcher who has long wrestled with the problem of how to prove the connection between prenatal stress and its effects on offspring is Prof. Marta Weinstock-Rosin of the Hebrew University of Jerusalem School of Pharmacy, who in her experimental work with rats has been able to demonstrate that relationship in a conclusive, laboratory-tested manner.
“There is an enormous advantage in working with rats,” says Weinstock-Rosen, “since we are able to eliminate the genetic and subjective element.” The researchers were able to compare the behavior of the offspring of stressed rat mothers with those whose mothers were not stressed. They also were able to compare the results of administering various types of stress at different periods during the gestation process to see which period is the most sensitive for the production of different behavioral alterations.
Weinstock-Rosin’s work, along with that of colleagues from Israel, the UK and elsewhere, will be presented at an international conference, “Long Term Consequences of Early Life Stress,” which she is co-chairing with Dr. Vivette Glover of the Imperial College, London, and that will be held at Mishkenot Sha’ananim in Jerusalem on October 29 and 30.
Weinstock-Rosin has been able to show through her laboratory experiments that when rat mothers were subject to stressful situations (irritating sounds at alternating times, for example), their offspring were later shown to have impaired learning and memory abilities, less capacity to cope with adverse situations (such as food deprivation), and symptoms of anxiety and depressive-like behavior, as compared to those rats in control groups that were born to unstressed mothers. All of these symptoms parallel the impairments that have been observed in children born to mothers who were stressed in pregnancy, she points out.
Further experiments by Weinstock-Rosin and her students have shown the crucial effect of excessive levels of the hormone cortisol that is released by the adrenal gland during stress and reaches the fetal brain during critical stages of brain development. Under normal conditions, this hormone has a beneficial function in supplying instant energy, but it has to be in small amounts and for a short period of time. Under conditions of excessive stress, however, the large amount of this hormone reaching the fetal brain can cause structural and functional changes. In humans, above-normal levels of cortisol can also stimulate the release of another hormone from the placenta that will cause premature birth, another factor that can affect normal development.
Weinstock-Rosin says that further experimental work is required in order to study possible other effects on the offspring resulting from raised hormonal levels. What does seem to be obvious already is that avoidance of stress to as great an extent as possible is a good prescription for a healthy pregnancy and healthy offspring.
Husbands take note!
For further information:Jerry Barach, Dept. of Media Relations, the Hebrew University,
Jerry Barach | Hebrew University
Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
23.06.2017 | Physics and Astronomy
23.06.2017 | Physics and Astronomy
23.06.2017 | Information Technology