Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Smoking can protect against Parkinson’s? Only with the right gene!

19.05.2010
American Academy of Neurology selects study by Mayo Clinic, Rochester (USA) and European Academy of Bozen/Bolzano

Smoking causes cancer, but it could protect against Parkinson’s disease. This has been demonstrated by various epidemiological studies, according to which there exists an inverse relationship between smoking and the probability of developing Parkinson’s disease.

The link is not however 100% clear, as some smokers develop the illness nevertheless. The hypothesis is that there is a genetic predisposition that, in combination with environmental factors, can trigger the disease. Taking this as its starting point, a team from the Mayo Clinic in Rochester, MN (USA) has carried out a study on a sample of 1228 subjects. The team includes Maurizio Facheris, a researcher at the Institute of Genetic Medicine at the European Academy of Bozen/Bolzano (EURAC), previous Research Fellow at the prestigious American clinic and who co-ordinated the study.

The researchers hypothesized that the variation may be due to pharmacogenetic effects and that nicotine might have neuroprotective properties for certain individuals.

... more about:
»CYP2A6 »EURAC »Neurology »Parkinson »Smoking

“We asked the interviewees to tell us about their relationship with smoking and then compared this data with the presence or absence of variations in the gene CYP2A6, which encodes the enzyme responsible for metabolising nicotine”, says EURAC researcher Maurizio Facheris, neurologist at the Department of Neurology of Bozen/Bolzano Central Hospital and main author of the study.

From an analysis of the data, it emerges that the presence of a particular variant of the gene, when combined with smoking, considerably reduces the risk of contracting Parkinson’s disease. It remains to be clarified whether the protection against the disease is provided by the particular variant of gene CYP2A6 or by the presence of cotinine, the substance into which nicotine is transformed through the action of the gene. “If this second hypothesis is confirmed, producing a cotinine-based drug would be a means to reduce exposure to the disease”, explains Maurizio Facheris.

The study opens up interesting scenarios in the field of pharmacogenetics, a discipline that holds that variations in different patients’ response to pharmacological treatment depends on genetic factors. Under this view, analysing the patients’ DNA will allow us to predict their reaction to a particular drug and thus enable the development of personalised medicines.

The study was presented at Toronto on the occasion of the annual convention of the American Academy of Neurology, and was selected as among the top 5% of over 2,000 articles received. It was the first study of its kind to be presented.

Laura Defranceschi | idw
Further information:
http://www.eurac.edu

Further reports about: CYP2A6 EURAC Neurology Parkinson Smoking

More articles from Studies and Analyses:

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>