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Sleeping in on the weekends doesn't fix all the deficits caused by workweek sleep loss

Article published in the American Journal of Physiology-Endocrinology and Metabolism

In many modern societies, adults often sacrifice sleep during the workweek to make time for other demands, then snooze longer on the weekends to recoup that lost sleep.

Research has shown that even a few days of lost sleep can have adverse effects, including increased daytime sleepiness, worsened daytime performance, an increase in molecules that are a sign of inflammation in the body, and impaired blood sugar regulation. These last two could be partially responsible for why sleeping less negatively affects health in other ways and shortens the lifespan.

Though many people believe they can make up sleep lost during the workweek by sleeping more on the weekend, it's unknown whether this "recovery" sleep can adequately reverse these adverse effects.

To help answer this question, researchers led by Alexandros N. Vgontzas of the Penn State University College of Medicine, placed 30 volunteers on a sleep schedule that mimicked a sleep-restricted workweek followed by a weekend with extra recovery sleep. At various points along this schedule, the researchers assessed the volunteers' health and performance using a variety of different tests.

The researchers found that the volunteers' sleepiness increased significantly after sleep restriction, but returned to baseline after recovery sleep. Levels of a molecule in blood that's a marker for the amount of inflammation present in the body increased significantly during sleep restriction, but returned to normal after recovery. Levels of a hormone that's a marker of stress didn't change during sleep restriction, but were significantly lower after recovery. However, the volunteers' measures on a performance test that assessed their ability to pay attention deteriorated significantly after sleep restriction and did not improve after recovery. This last result suggests that recovery sleep over just a single weekend may not reverse all the effects of sleep lost during the workweek.

The study is entitled "The Effects of Recovery Sleep After One Workweek of Mild Sleep Restriction on Interleukin-6 and Cortisol Secretion and Daytime Sleepiness and Performance." It appears in the American Journal of Physiology-Endocrinology and Metabolism, published by the American Physiological Society. The article is available online at


The researchers recruited 30 healthy adults who were normal sleepers and put them on a 13-day schedule that involved spending nights in a sleep lab. For the first four nights, the subjects were allowed to sleep for 8 hours, setting a baseline for a healthy, normal amount of sleep. For the next six nights, the researchers woke the subjects up 2 hours earlier. For the following three nights, the subjects were allowed to sleep for 10 hours. The researchers monitored the volunteers' brain waves during these sleep sessions. At three points during the 13-day schedule, the volunteers spent whole days at the lab taking part in various tests: after the 4 days of baseline sleep, after 5 days of restricted sleep, and after 2 days of recovery sleep. On these days, the subjects had catheters inserted into their arms, and the researchers sampled blood every hour, testing it for levels of interleukin-6 (a marker of inflammation) and cortisol (a hormone secreted during stress). They also participated in a test of how quickly they fell asleep when allowed to nap several times during those days (an objective measure of sleepiness) and filled out questionnaires to assess how sleepy they felt (a subjective measure of sleepiness). To assess their performance, they participated in a test in which they were asked to press a button whenever a dot appeared on a screen, which measured how well they were able to pay attention.


Not surprisingly, the researchers found that after 5 days of restricted sleep, the subjects were significantly sleepier on both objective and subjective tests compared to baseline levels. Their interleukin-6 levels increased sharply during restricted sleep, though their cortisol levels remained the same. Their performance on the attention test deteriorated. After 2 days of recovery sleep, both objective and subjective tests showed that the volunteers were less sleepy. Their interleukin-6 levels reduced, and their cortisol levels decreased significantly compared to baseline, possibly suggesting that the volunteers were sleep deprived before the study started. Notably, their performance on the attention test didn't improve after recovery sleep.

Importance of the Findings

Though many indicators of health and well being improved after recovery sleep, these findings suggest that extra sleep may not fix all the deficits caused by lost sleep during the workweek.

"Two nights of extended recovery sleep may not be sufficient to overcome behavioral alertness deficits resulting from mild sleep restriction," the authors write. "This may have important implications for people with safety-critical professions, such as health-care workers, as well as transportation system employees (drivers, pilots, etc.)."

The authors also suggest that even though these results provide some insight on the health effects of a single week of sleep loss and recovery, reliving the cycle over and over again may have more significant health effects that this study wouldn't show.

"The long-term effects of a repeated sleep restriction/sleep recovery weekly cycle in human remains unknown," they write.

Study Team

In addition to Dr. Vgontzas, the study was conducted by Slobodanka Pejovic, Ilia Kritikou, Michele L. Shaffer, and Edward O. Bixler of Pennsylvania State University, Maria Basta of Pennsylvania State University and the University of Crete, Marina Tsaoussooglou and George P. Chrousos of National and Kapodistrian University of Athens, David Stiffler of Pennsylvania State University and the New York School of Medicine, and Zacharias Stefanakis of the University of Crete.

Physiology is the study of how molecules, cells, tissues, and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first US society in the biomedical sciences field. The Society represents more than 11,000 members and publishes 14 peer-reviewed journals with a worldwide readership.

NOTE TO EDITORS: To schedule an interview with a member of the research team, please contact Donna Krupa at, @Phyziochick, or 301.634.7209. The article is available online at

Donna Krupa | EurekAlert!
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