Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Single Men, Smokers at Higher Risk for Oral Human Papillomavirus Infection, Moffitt Cancer Center Study Shows

03.07.2013
Smokers and single men are more likely to acquire cancer-causing oral human papillomavirus (HPV), according to new results from the HPV Infection in Men (HIM) Study. Researchers from Moffitt Cancer Center, the National Cancer Institute, Mexico and Brazil also report that newly acquired oral HPV infections in healthy men are rare and when present, usually resolve within one year.
The study results appeared in the July issue of The Lancet.

HPV infection is known to cause virtually all cervical cancers, most anal cancers and some genital cancers. It has recently been established as a cause of the majority of oropharyngeal cancers, a malignancy of the tonsils and base of tongue.

HPV-related oropharyngeal cancer is rare, but rates have been increasing rapidly, especially among men. To determine the pattern of HPV acquisition and persistence in the oral region, researchers evaluated the HPV infection status in oral mouthwash samples collected as part of the HIM Study, which was originally designed to evaluate the natural history of genital HPV infections in healthy men.

“Some types of HPV, such as HPV16, are known to cause cancer at multiple places in the body, including the oral cavity,” said study lead author Christine M. Pierce Campbell, Ph.D., M.P.H., a postdoctoral fellow in Moffitt’s Center for Infection Research in Cancer. “We know that HPV infection is associated with oropharyngeal cancer, but we don’t know how the virus progresses from initial infection to cancer in the oral cavity. One aspect of the HIM Study is to gather data to help us understand the natural history of these infections.”

During the first 12 months, nearly 4.5 percent of men in the study acquired an oral HPV infection. Less than 1 percent of men in the study had an HPV16 infection, the most commonly acquired type, and less than 2 percent had a cancer-causing type of oral HPV.

Their findings are consistent with previous studies showing a low prevalence of oral HPV cancers. However, this study shows the acquisition of cancer-causing oral HPV appeared greater among smokers and unmarried men.

“Additional HPV natural history studies are needed to better inform the development of infection-related prevention efforts,” said Anna R. Giuliano, Ph.D., director of Moffitt’s Center for Infection Research in Cancer. “HPV16 is associated with the rapid increase in incidence of oropharyngeal cancer, most noticeably in the United States, Sweden and Australia, where it is responsible for more than 50 percent of cases. Unfortunately, there are no proven methods to prevent or detect these cancers at an early stage.”

The researchers note that persistent oral HPV16 infection may be a precursor to oropharyngeal cancer, similar to how persistent cervical HPV infection leads to cervical pre-cancer.

Funding for the study was provided by National Cancer Institute grants (CA R01CA098803, R25T CA147832) and the National Cancer Institute Intramural Research Program.

About Moffitt Cancer Center
Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt’s excellence in research, its contributions to clinical trials, prevention and cancer control. Since 1999, Moffitt has been listed in U.S. News & World Report as one of “America’s Best Hospitals” for cancer. With more than 4,200 employees, Moffitt has an economic impact on the state of nearly $2 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, twitter and YouTube.

Media release by Florida Science Communications

Kim Polacek | EurekAlert!
Further information:
http://www.moffitt.org

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

DGIST develops 20 times faster biosensor

24.04.2017 | Physics and Astronomy

Nanoimprinted hyperlens array: Paving the way for practical super-resolution imaging

24.04.2017 | Materials Sciences

Atomic-level motion may drive bacteria's ability to evade immune system defenses

24.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>