Allan J. Walkey, MD, assistant professor of medicine at BUSM and a pulmonologist at Boston Medical Center (BMC), is the lead author of the study, which will be published in the Journal of the American Medical Association. Walkey also will present the findings at the American Heart Association's annual Scientific Sessions in Orlando, Fla., on Sunday, Nov. 13, at 4:45 p.m. ET.
Severe sepsis is the 10th leading cause of death in the United States, and atrial fibrillation affects one in four people over the age of 40. While both are common illnesses, and chronic atrial fibrillation is a known risk factor for stroke and death, very little is known about new-onset atrial fibrillation during severe sepsis.
"The purpose of our retrospective study was to examine if a new-onset atrial fibrillation diagnosis in patients with severe sepsis was associated with an increased the risk of stroke and mortality in a hospital setting," said Walkey.
The researchers examined data, provided by the Agency for Healthcare Research and Quality, from more than three million hospitalized patients. Looking at the risks of stroke and mortality, patients with new- onset atrial fibrillation during severe sepsis had three times the risk of having a stroke and a seven percent increased risk of death during hospitalization. Almost three percent of patients with new-onset atrial fibrillation during severe sepsis had a stroke during hospitalization compared to less than one percent of those not diagnosed with the condition during severe sepsis.
The data also showed that 56 percent of patients with severe sepsis and new-onset atrial fibrillation died, whereas 39 percent of patients with severe sepsis who did not develop new-onset atrial fibrillation did not. Additionally, six percent of patients with severe sepsis developed new-onset atrial fibrillation compared to less than one percent of patients who did not have severe sepsis and were hospitalized for another reason. Furthermore, among all patients with or without severe sepsis, 14 percent of all new-onset atrial fibrillation cases occurred in patients with severe sepsis.
"It is projected that one million Americans will have severe sepsis this year, and based on our data, approximately 60,000 people will develop new-onset atrial fibrillation," said Walkey. "There are currently no guidelines on how best to care for these specific patients, but this study is a call to action that this under-recognized potential complication of severe sepsis requires further investigation on how to treat these critically ill patients."
This research was funded by that National Institutes of Health's National Heart Lung and Blood Institute.
About Boston University School of Medicine
Originally established in 1848 as the New England Female Medical College, and incorporated into Boston University in 1873, Boston University School of Medicine today is a leading academic medical center with an enrollment of more than 700 medical students and more than 800 masters and PhD students. Its 1,246 full and part-time faculty members generated more than $335 million in funding in the 2009-2010 academic year for research in amyloidosis, arthritis, cardiovascular disease, cancer, infectious disease, pulmonary disease and dermatology among others. The School is affiliated with Boston Medical Center, its principal teaching hospital, the Boston and Bedford Veterans Administration Medical Centers and 16 other regional hospitals as well as the Boston HealthNet.
Jenny Eriksen Leary | EurekAlert!
Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
23.06.2017 | Physics and Astronomy
23.06.2017 | Physics and Astronomy
23.06.2017 | Information Technology