Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

How often to screen for colon cancer? NEJM study finds 5-year risk extremely low

18.09.2008
How frequently should symptom-free individuals at average risk for colon cancer undergo screening with colonoscopy?

In a study published in the Sept. 18, 2008, New England Journal of Medicine, researchers led by Thomas F. Imperiale, M.D., of the Indiana University School of Medicine and the Regenstrief Institute, report that while there still is no definitive answer to the question, they now know the procedure need not be performed any sooner than every five years.

This is the first large study to systematically rescreen a group of average risk individuals who had normal findings from an initial colonoscopy. The rescreening showed that after five years they remained cancer free.

All 1,256 participants in the study were 50 years or older, had undergone a first-time screening with no cancer or pre-cancerous findings, and had no symptoms of colon cancer such as rectal bleeding, change of bowel habits or unexplained weight loss during the 5 year interval between screenings.

"The American Cancer Society and other guideline organizations call for colonoscopic screenings every 10 years but these recommendations are based on extrapolated, indirect data. No study has rescreened a large number of individuals ten years after a normal initial colonoscopy. Our study didn't assess whether the recommendation of 10-year screening interval for colonoscopy is 'right on' but we did determine that the appropriate screening interval can be more than 5 years for average risk individuals. Frankly, we don't know the optimal time interval between screenings," said Dr. Imperiale, who is a gastroenterologist and begins to discuss rescreening with his own patients 7 to 8 years after a previous normal exam unless they develop symptoms or have a family history of colon cancer in a first-degree relative.

The risk of colon cancer increases with age. Changes in lifestyle behaviors such as smoking, alcohol consumption and physical activity also can affect risk.

"I try to tailor my rescreening recommendation to the individual patient. The interval and what rescreening method to use – colonoscopy, virtual colonoscopy, fecal occult blood testing -- are all factors we discuss, said Dr. Imperiale, who is a professor of medicine at the IU School of Medicine and a member of the Indiana University Melvin and Bren Simon Cancer Center.

"Determination of the appropriate frequency of rescreening for persons with normal findings on initial screening colonoscopy could have a substantial effect on the cost of colonoscopy and the capacity to provide it," the study notes. And, adds Dr. Imperiale, who is a clinical epidemiologist and an affiliate investigator of the Center on Implementing Evidence-based Practices at the Roudebush VA Medical Center, it may impact the likelihood that individuals will return for rescreening.

According to the American Cancer Society, "colorectal cancer is the third leading cause of cancer-related deaths in the United States when men and women are considered separately, and the second leading cause when both sexes are combined. It is expected to cause about 49,960 deaths (24,260 men and 25,700 women) during 2008."

In addition to Dr. Imperiale, authors of the study are Elizabeth A. Glowinski, R.N., Indianapolis Gastroenterology Research Foundation; Ching Lin-Cooper, B.S., IU School of Medicine; Gregory N. Larkin, M.D., Eli Lilly; James D. Rogge, M.D., Indianapolis Gastroenterology Research Foundation; and David F. Ransohoff, M.D., University of North Carolina.

The study was funded, in part, by the National Institute of Diabetes and Digestive and Kidney Diseases.

Cindy Fox Aisen | EurekAlert!
Further information:
http://www.iupui.edu

Further reports about: Cancer Colonoscopy Gastroenterology NEJM colon cancer

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>