In a study published in the Sept. 18, 2008, New England Journal of Medicine, researchers led by Thomas F. Imperiale, M.D., of the Indiana University School of Medicine and the Regenstrief Institute, report that while there still is no definitive answer to the question, they now know the procedure need not be performed any sooner than every five years.
This is the first large study to systematically rescreen a group of average risk individuals who had normal findings from an initial colonoscopy. The rescreening showed that after five years they remained cancer free.
All 1,256 participants in the study were 50 years or older, had undergone a first-time screening with no cancer or pre-cancerous findings, and had no symptoms of colon cancer such as rectal bleeding, change of bowel habits or unexplained weight loss during the 5 year interval between screenings.
"The American Cancer Society and other guideline organizations call for colonoscopic screenings every 10 years but these recommendations are based on extrapolated, indirect data. No study has rescreened a large number of individuals ten years after a normal initial colonoscopy. Our study didn't assess whether the recommendation of 10-year screening interval for colonoscopy is 'right on' but we did determine that the appropriate screening interval can be more than 5 years for average risk individuals. Frankly, we don't know the optimal time interval between screenings," said Dr. Imperiale, who is a gastroenterologist and begins to discuss rescreening with his own patients 7 to 8 years after a previous normal exam unless they develop symptoms or have a family history of colon cancer in a first-degree relative.
The risk of colon cancer increases with age. Changes in lifestyle behaviors such as smoking, alcohol consumption and physical activity also can affect risk.
"I try to tailor my rescreening recommendation to the individual patient. The interval and what rescreening method to use – colonoscopy, virtual colonoscopy, fecal occult blood testing -- are all factors we discuss, said Dr. Imperiale, who is a professor of medicine at the IU School of Medicine and a member of the Indiana University Melvin and Bren Simon Cancer Center.
"Determination of the appropriate frequency of rescreening for persons with normal findings on initial screening colonoscopy could have a substantial effect on the cost of colonoscopy and the capacity to provide it," the study notes. And, adds Dr. Imperiale, who is a clinical epidemiologist and an affiliate investigator of the Center on Implementing Evidence-based Practices at the Roudebush VA Medical Center, it may impact the likelihood that individuals will return for rescreening.
According to the American Cancer Society, "colorectal cancer is the third leading cause of cancer-related deaths in the United States when men and women are considered separately, and the second leading cause when both sexes are combined. It is expected to cause about 49,960 deaths (24,260 men and 25,700 women) during 2008."
In addition to Dr. Imperiale, authors of the study are Elizabeth A. Glowinski, R.N., Indianapolis Gastroenterology Research Foundation; Ching Lin-Cooper, B.S., IU School of Medicine; Gregory N. Larkin, M.D., Eli Lilly; James D. Rogge, M.D., Indianapolis Gastroenterology Research Foundation; and David F. Ransohoff, M.D., University of North Carolina.
The study was funded, in part, by the National Institute of Diabetes and Digestive and Kidney Diseases.
Cindy Fox Aisen | EurekAlert!
The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft
Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...
Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.
Cell Press has just released the first issue of Joule, a new journal dedicated to sustainable energy research. In this issue James Birrell, Olaf Rüdiger,...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
19.09.2017 | Event News
19.09.2017 | Physics and Astronomy
19.09.2017 | Power and Electrical Engineering