Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers identify a mechanism linking bariatric surgery to health benefits

23.04.2014

Bariatric surgery has positive effects not only on weight loss but also on diabetes and heart disease. Researchers at the Sahlgrenska Academy and University of Cincinnati have shown that the health benefits are not caused by a reduction in the stomach size but by increased levels of bile acids in the blood. These findings, reported in Nature, indicate that bile acids could be a new target for treating obesity and diabetes.

Previous research from the Sahlgrenska Academy has demonstrated that obesity surgery is the only effective treatment for obesity and obesity-related diabetes.

However, the mechanisms that cause the positive effects have been unclear.

Positive effects caused by bile acids
Professor Fredrik Bäckhed, in collaboration with Randy Seeley and coworkers from the University of Cincinnati in the US, has shown that the positive effects of bariatric surgery are likely caused by the surgery-induced increase in bile acids. The study, which is published online in the leading science journal Nature, focuses on a specific receptor called FXR, which is involved in bile acid signaling.

"Our study shows that signaling through FXR is essential for the beneficial effects of the surgery to be achieved. This is a major breakthrough in understanding how bariatric surgery affects metabolism and in the development of new treatment strategies", says Fredrik Bäckhed.

Important future complement
The prevalence of obesity is increasing worldwide and it is not realistic to operate on all obese subjects. Furthermore, bariatric surgery is associated with a risk of complications. Treatment strategies based on the FXR receptor could therefore be an important future therapeutic approach.

Improves glucose metabolism
In this study, mice with or without the FXR gene underwent an operation termed vertical sleeve gastrectomy (VSG) in which approximately 80 percent of the stomach was removed. The surgical procedure is the same as that performed in humans.

The researchers observed that the operation promoted weight loss and improved glucose metabolism in mice with FXR while the operation had no effect in mice that lacked FXR.

Alters intestinal bacterial flora
This study also showed that VSG resulted in changes in the gut microbiota, a potentially important finding given that Fredrik Bäckhed’s research group has previously demonstrated that the intestinal bacterial flora is altered in obesity and diabetes.

"These additional findings suggest that an altered gut flora together with signaling through FXR may contribute to improved metabolism. This means that future treatments based on the intestinal flora could help in the treatment of diabetes."

The article FXR is a molecular target for the effects of vertical sleeve gastrectomy was published online in Nature on 26 March.

Link to the journal: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13135.html

Contact:
Fredrik Bäckhed, Professor at the Sahlgrenska Academy and Director of the Wallenberg Laboratory, University of Gothenburg
+4631-342 7833
+4670-2182355
fredrik.backhed@wlab.gu.se
http://www.wlab.gu.se/backhed

Weitere Informationen:

http://sahlgrenska.gu.se/english/news_and_events/news/News_Detail/researchers-id...

Krister Svahn | idw - Informationsdienst Wissenschaft

Further reports about: Researchers Treatment mechanism metabolism obesity receptor strategies therapeutic

More articles from Studies and Analyses:

nachricht Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>