Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers explore role of fungus in digestive disorders

08.06.2012
Study published in Science indicates that fungus plays a role in Inflammatory Bowel Disease (IBD)

Cedars-Sinai researchers say their examination of the fungi in the intestines suggests an important link between these microbes and inflammatory diseases such as ulcerative colitis.

In the new study, published in the June 8 issue of Science, researchers at Cedars-Sinai’s Inflammatory Bowel and Immunobiology Research Institute identified and characterized the large community of fungi inhabiting the large intestine in a model of the disease.

The digestive tract is home to a large number of micro-organisms. In fact, with an estimated 100 trillion bacteria residing in the gut, microbes outnumber human cells in the body. Some are necessary to aid in digesting food, producing necessary vitamins and suppressing the growth of harmful microbes. Others are harmful to the body, contributing to illnesses such as Crohn’s disease, ulcerative colitis and obesity.

Modern DNA-sequencing technology has revolutionized the study of these microbes in the last decade, allowing the role of bacteria in disease to be understood more clearly, as is shown in the Cedars-Science research published in Science.

“It’s long been recognized that fungi must also exist in the gut, but we’re among the first to investigate what types, how many, and whether they’re important in disease,” said David Underhill, PhD, associate professor and director of the Graduate Program in Biomedical Science and Translational Medicine, who led the study. “We were truly stunned to see just how common fungi are, identifying more than 100 different types” and seeing linkages to digestive disorders.

An estimated 1.4 million Americans have Inflammatory Bowel Disease, or IBD, a chronic digestive disorder, and about 30,000 new cases are diagnosed annually. Ulcerative colitis, one of the most common types of IBD, causes inflammation and ulcers in the top layers of the lining of the large intestine. Common symptoms include abdominal pain, diarrhea, bleeding, fatigue, weight loss and loss of appetite. Ulcerative colitis patients can be at increased risk of developing colorectal cancer.

“This study takes us an important step closer to understanding how fungi contribute to disease, as well as significantly expanding our understanding of what types of fungi are living in our bodies,” said Iliyan Iliev, PhD, a Cedars-Sinai research scientist and lead author on the study.

To determine fungi contribute to inflammatory disease, the study homed in on a protein called Dectin-1, produced by white blood cells and used by the immune system to detect and kill fungi. In an animal model of the disease, researchers found that the protein is important in protecting against inflammation caused by indigenous fungi. The finding has significant implications for human disease, as scientists at the Cedars-Sinai Medical Genetics Institute found a variant of the gene for Dectin-1 that is strongly associated with severe forms of ulcerative colitis.

Nicole White | Cedars-Sinai News
Further information:
http://www.cshs.org

More articles from Studies and Analyses:

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

nachricht A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>