Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Reports claiming ALS caused by head trauma lacks scientific validation

19.11.2010
Editorial sets record straight -- Lou Gehrig suffered from Lou Gehrig's disease

A recent study (1) suggesting that amyotrophic lateral sclerosis (ALS) may be attributed to "repetitive head trauma experienced in collision sports" lacks scientific epidemiological evidence to support this claim.

In a review of the 12-patient study, several experts specializing in motor neuron diseases challenge the findings as entirely pathological and without clinical merit. Their editorial, which aims to dispel doubts of Lou Gehrig's ALS diagnosis, is now available online in the peer-reviewed journal Muscle & Nerve.

ALS, also known as Lou Gehrig's disease, is a progressive neurological disease that attacks nerve cells (neurons) in the brain and spinal cord which control voluntary muscles. As the upper and lower motor neurons degenerate, the muscles they control gradually weaken and waste away, leading to paralysis. Other symptoms of ALS include difficulty breathing, issues with swallowing (gagging, choking), and speech problems. According to the National Institutes of Neurological Disorders and Stroke roughly 20,000 to 30,000 Americans have ALS, and 5,000 patients are diagnosed annually with the disease.

In the editorial, the authors cite two media reports—"Brain Trauma Can Mimic Lou Gehrig's Disease" in the New York Times and "Maybe Lou Gehrig Didn't Die of Lou Gehrig's Disease" in Time magazine—as lacking in scientific validation. These reports have led to numerous inquiries from ALS patients who are seeking answers from their physicians.

"Media coverage generated by the McKee et al. study has caused much concern for our ALS patients who now believe they may be misdiagnosed," said Dr. Stanley H. Appel, Chairman of the Department of Neurology at the Methodist Hospital in Houston, Texas, and one of the foremost experts on Lou Gehrig's disease. "We want to make it clear to physicians and their ALS patients that reports of Lou Gehrig succumbing to anything but the disease which bears his name are inaccurate."

The study in question reported pathological changes of chronic traumatic encephalopathy (CTE) in 12 patients, 3 of whom displayed both the TAR DNA-binding protein (TDP-43) and tau in their spinal cords. The build-up of toxic proteins contributes to a number of neurodegenerative diseases, with TDP-43 found in most ALS cases and tau more commonly associated with dementia. Based on the findings of both proteins in the 3 subjects, the study authors concluded that head trauma and CTE led to an "ALS-like" condition, which one author during media interviews, suggested naming chronic traumatic encephalomyopathy (CTEM).

"There is no clinical or pathological evidence of muscle disease reported in the study that would support a diagnosis of CTEM," added Valerie Cwik, M.D., Executive Vice President and Medical Director for the Muscular Dystrophy Association, and co-author of the editorial. "More likely their 3 patients with CTE and ALS had the two distinct diseases."

The editorial authors maintain that an ALS diagnosis is established when patients meet well-defined clinical criteria rather than identification of pathological findings. Editorial contributor, John W. Day, M.D., Ph.D., Director of the Muscular Dystrophy Clinic at the University of Minnesota Medical Center concluded, "Further studies are needed to fully understand the potential role of trauma in ALS and investigation of TDP-43 and tau as potential targets for therapeutic interventions are warranted."

1 McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, et al. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol 2010; 69:918-929.

This editorial is published in Muscle & Nerve. Media wishing to receive a PDF of the article may contact healthnews@wiley.com.

Full citation: "Trauma, TDP-43, and Amyotrophic Lateral Sclerosis." Stanley H. Appel, Valerie A. Cwik and John W. Day. Muscle & Nerve; Published Online: November 19, 2010; (DOI: 10.1002/mus.21939); Print Issue Date: December 2010. Upon publication this link will take you to the editorial: http://doi.wiley.com/10.1002/mus.21939.

Further Reading On Amyotrophic Lateral Sclerosis is Available From Wiley-Blackwell as Free Downloads. Please visit: http://www.wiley.com/WileyCDA/PressRelease/pressReleaseId-86857,descCd-release_additional_material.html.

Muscle & Nerve is an international and interdisciplinary publication of original contributions, in both health and disease, concerning studies of the muscle, the neuromuscular junction, the peripheral motor, sensory and autonomic neurons, and the central nervous system where the behavior of the peripheral nervous system is clarified. Appearing monthly, Muscle & Nerve publishes clinical studies and clinically relevant research reports in the fields of anatomy, biochemistry, cell biology, electrophysiology and electrodiagnosis, epidemiology, genetics, immunology, pathology, pharmacology, physiology, toxicology, and virology. For details on the journal, please visit http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4598.

The American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) was founded in 1953 and is a nonprofit membership association dedicated to the advancement of neuromuscular, musculoskeletal, and electrodiagnostic (EDX) medicine. More than 5000 physician members -- primarily neurologists and physiatrists -- are joined by allied health professionals and PhD Researchers working to improve the quality of medical care to patients with muscle and nerve disorders. For information on AANEM, please visit http://www.aanem.org.

Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit www.wileyblackwell.com or our new online platform, Wiley Online Library (wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.

Dawn Peters | EurekAlert!
Further information:
http://www.wiley.com

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Microhotplates for a smart gas sensor

22.02.2017 | Power and Electrical Engineering

Scientists unlock ability to generate new sensory hair cells

22.02.2017 | Life Sciences

Prediction: More gas-giants will be found orbiting Sun-like stars

22.02.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>