Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study finds genetic testing may help people with severe type of migraine

04.12.2007
People with a severe type of migraine in which one side of the body becomes weak should consider genetic testing, according to research that has found familial genes for this type of migraine in people who did not have family members experiencing the problem. The findings are published in the December 4, 2007, issue of Neurology®, the medical journal of the American Academy of Neurology.

“Our findings have important clinical implications,” said study author Michel D. Ferrari, MD, PhD, with Leiden University Medical Centre in the Netherlands. “Since many people with this type of migraine are initially misdiagnosed and not given the proper treatment, understanding the genetic basis of this type of migraine may help clinicians in diagnosing and treating the problem. Most patients are initially diagnosed with epilepsy, stroke or other disorders and are treated accordingly with non-effective medications that are associated with a high risk of side effects rather than with effective agents to treat migraine.”

For the study, genetic testing was performed on 39 men and women with sporadic hemiplegic migraine, which is a rare, often severe subtype of migraine with aura in which attacks are associated with a weakness affecting one side of the body. The participants, who had no known family members with this type of migraine, were screened for mutations in the three known genes for familial hemiplegic migraine: the CACNA1A gene, the ATPIA2 gene, and the SCN1A gene.

The study found variants of these familial genes in 18 percent of the study participants. Variants in the ATPIA2 gene were the most prevalent.

Ferrari says screening for familial genes in people with this type of sporadic migraine may also help to enable counseling and prevent unnecessary treatment with potentially harmful drugs.

“Our findings reinforce the growing evidence that familial and sporadic hemiplegic migraine along with normal migraine have some shared gene pathways. Unraveling these pathways may help to identify new treatment options,” said Ferrari.

Angela Babb | EurekAlert!
Further information:
http://www.aan.com

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

From rocks in Colorado, evidence of a 'chaotic solar system'

23.02.2017 | Physics and Astronomy

'Quartz' crystals at the Earth's core power its magnetic field

23.02.2017 | Earth Sciences

Antimicrobial substances identified in Komodo dragon blood

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>