Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A maternal link to Alzheimer's disease

08.11.2007
People who have a mother with Alzheimer’s disease appear to be at higher risk for getting the disease than those individuals whose fathers are afflicted, according to a new study by NYU School of Medicine researchers.

The study is published in this week’s online edition of the Proceedings of the National Academy of Sciences. It is the first to compare brain metabolism among cognitively normal people who have a father, a mother, or no relatives with Alzheimer’s disease, and to show that only individuals with an affected mother have reduced brain metabolism in the same brain regions as Alzheimer’s patients.

Over the last two decades a number of studies have shown that people with the disease have significant reductions in brain energy metabolism in certain regions of the brain. In some recent research studies these reductions are evident in healthy people years before symptoms of dementia emerge.

The researchers wanted to evaluate people with a family history of Alzheimer’s because that is one of the biggest risk factors for the disease. Alzheimer’s affects more than 5 million Americans and is the most common form of senile dementia. People with an affected parent have a 4- to 10-fold higher risk compared to individuals with no family history. It isn’t known why people with a family history are more susceptible to the disease.

Likewise, it isn’t known why individuals with a history of the disease on their mother’s side are at increased risk for Alzheimer’s, and this observation must be replicated in larger studies before it could be of use in the clinic to perhaps identify people who may be more vulnerable to the disease, says Lisa Mosconi, Ph.D., Research Assistant Professor of Psychiatry at NYU School of Medicine, who led the new study. She speculates that genes that are maternally inherited might alter brain metabolism.

The new study involved 49 cognitively normal individuals, from 50 to 80 years old, who underwent a battery of neuropsychological and clinical tests, and PET (positron emission tomography) scans of their brains using a technique that labels glucose—the brain’s fuel—with a special chemical tracer. Sixteen subjects had a mother with the disease, and eight had a father with Alzheimer’s. The remaining subjects didn’t have a family history of the disease.

People with a maternal history of the disease had the largest reductions in glucose metabolism in several areas of the brain, including the medial temporal lobes and the posterior cingulate cortex, two brain regions involved with memory storage and retrieval. Brain energy metabolism was reduced by 25 percent in the posterior cingulate cortex in this group

There weren’t any reductions in brain energy metabolism in the people without a family history and in those with a father who had the disease. The effects in glucose metabolism among subjects with a maternal history remained significant after accounting for possible risk factors for Alzheimer’s, including age, gender, education, Apolipoprotein E genotype, and subjective memory complaints.

“This is a preliminary study and the results have to be replicated,” says Dr. Mosconi. “What we need even more is to follow subjects over time until they develop clinical symptoms, and we really need to assess whether the metabolic reductions predict and correlate with disease progression,” she says.

“Energy metabolism hasn’t been a major focus of research in Alzheimer’s, so we hope that this study will stimulate further discussion on brain activity and disease risk, which could also be important for planning targeted therapeutic interventions,” says Dr. Mosconi.

“This is an intriguing finding,” says Mony de Leon, Ed.D., Professor of Psychiatry and Director of the Center for Brain Health at NYU School of Medicine. “It points to the need for more research to investigate the mechanisms of maternal transmission of this observed glucose metabolism deficit as well as to learn of any direct or indirect relationship to Alzheimer's disease," said Dr. de Leon.

Pamela McDonnell | alfa
Further information:
http://www.nyumc.org

More articles from Studies and Analyses:

nachricht Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

Im Focus: Optoelectronic Inline Measurement – Accurate to the Nanometer

Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.

New Manufacturing Technologies for New Products

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

New technique makes brain scans better

22.06.2017 | Medical Engineering

CWRU researchers find a chemical solution to shrink digital data storage

22.06.2017 | Life Sciences

Warming temperatures threaten sea turtles

22.06.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>