Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MU research team makes progress toward 'printing' organs

08.11.2007
Biology-based process maintains cell properties and lets nature do the rest

Each year, pharmaceutical companies invest millions of dollars to test drugs, many of which will never reach the market because of side effects found only during human clinical trials. At the same time, the number of patients waiting for organ transplants continues to increase. In the past 10 years, this number has nearly doubled. Now, a new study led by a University of Missouri-Columbia physics researcher might present new solutions to both problems with the help of a very special printer.

For the past four years, Gabor Forgacs, the George H. Vineyard Professor of Physics in the MU College of Arts and Science, has been working to refine the process of “printing” tissue structures of complex shape with the aim of eventually building human organs. In the latest study, a research team led by Forgacs determined that the process of building such structures by printing does not harm the properties of the composing cells and the process mimics the naturally occurring biological assembly of living tissues.

In the study, the team used bio-ink particles, or spheres containing 10,000 to 40,000 cells, and assembled, or “printed,” them on to sheets of organic, cell friendly “bio-paper.” Once printed, the spheres began to fuse in the bio-paper into one structure, much the same way that drops of water will fuse to form a larger drop of water.

“If you wait for a long time, eventually all the small spheres will fuse into one large sphere,” Forgacs said. “To prevent that from happening, we can remove the bio-paper and stop the fusion process once the desired shape has formed. Through this bio-printing process, we were able to build, for the first time, functional tissue structures.”

In the past, there have been two concerns with printing extended tissue structures using large amounts of cells. First, scientists needed to determine how to get specific cells to the correct locations within the structures. Second, even though the right cells might be in the right place within the structure, there was a problem of function. How do you make an organ start working?

As the Mizzou research team found in the study, there appears to be no need to worry about either of these concerns. As the tissue structure begins to form, the cells go through a natural process called “sorting,” which is nature’s way of determining where specific cells need to be. For example, an artery has three specific types of cells – endothelial cells, smooth muscle cells and fibroblast cells, each type needing to be in a specific location in the artery. As thousands and thousands of cells are added to the bio-paper under controlled conditions, the cells migrate automatically to their specific locations to make the structure form correctly.

The team also found that nature was the answer to the second question. In the study, scientists took cells from a chicken heart and used them to form bio-ink particles, which were then printed on to thick sheets. Heart cells must be synchronized for the heart to beat properly. When the bio-ink particles were first printed, the cells did not beat in unison, but as the cellular spheroids fused, the structure eventually started beating just as a heart does.

“This study shows that we can use multiple cell types and that we do not have to control what happens when the cells fuse together,” Forgacs said. “Nature is smart enough to do the job.”

The study is being published in an upcoming edition of Tissue Engineering and was funded by a $5 million grant from the National Science Foundation. Forgacs also has become involved with a company, Organovo, Inc., which is interested in licensing the technology. He also plans to work with drug companies to provide them with tissues they can use to test drugs, prior to human clinical trials.

Currently, drugs are tested first on animals and then go through a human clinical stage. Because of the major differences in biological function, humans often have different reactions than animals. Forgacs believes that providing human tissue structures that resemble organs to the drug companies will make drug testing cheaper and much more efficient.

Christian Basi | EurekAlert!
Further information:
http://www.missouri.edu

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>