The study, by Rinah Yamamoto and colleagues at McLean Hospital in Belmont, Massachusetts assessed the suspected link by contrasting reactions to varying perceived availability of the drug. The researchers suggest that more appropriate care could be given if the degree of dependency and abuse were assessed in a natural environment with a potential access to the drug, rather than in a clinical setting.
Yamamoto explains that craving, is an intense and often irrepressible urge to seek and consume the drug, which can result in relapses even after extended periods of abstinence. In searching for effective therapies, understanding how craving, cognition and motivation are entwined is essential.
The researchers administered intravenous cocaine (0.2 mg/kg) to individuals with cocaine dependence who were not seeking treatment. "Unblinded" participants knew for certain they would receive cocaine, while the "blinded" group knew there was a 33 percent chance of getting the drug. The researchers obtained subjective ratings of craving, high, rush and low from the volunteers along with their heart rate and blood pressure measurements. Measurements were collected prior to cocaine administration and every minute for 20 minutes thereafter.
The results showed that several hours prior to the infusion all volunteers had similar craving scores. However, those volunteers who knew they were to receive a cocaine infusion said they felt a greater craving immediately prior to the receipt of cocaine than the "blinded" volunteers who did not know whether the infusion was placebo or the genuine drug. The team also found that the unblinded subjects experienced a more rapid onset of high and rush cocaine responses along with significantly higher cocaine-induced heart rate elevations.
The findings suggest that the cocaine expectancy state modulates the user's subjective and objective responses to the drug. These data are consistent with the previous studies demonstrating that drug-induced elevated dopamine concentrations in the brain may prime drug users to associate the cues around the source of dopamine boost (e.g., cocaine) with the pleasure experienced once the drug is taken.
Charlotte Webber | alfa
Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)
The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
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10.10.2017 | Event News
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