The international team from the US, UK and Finland studied the maternity records of more than 6,000 women born in Helsinki from 1934 to 1944 whose mothers' pelvic bones were measured during routine antenatal care. They found that breast cancer rates were more than three times higher among the women, born at or after term, whose mothers had wide hips. Rates were more than seven times higher if those mothers had already given birth to one or more children.
'Wide, round hips represent markers of high sex hormone concentrations in the mother, which increase her daughter's vulnerability to breast cancer,' comments David Barker, who is a professor in the Developmental Origins of Health and Disease Division of the University of Southampton's School of Medicine, and also on the faculty of Oregon Health & Science University.
'A woman's hips are shaped at puberty when the growth of her hip bones is controlled by sex hormones, and also influenced by the level of nutrition. Every woman has a unique sex hormone profile which is established at puberty and persists through her reproductive life.
'Our findings show for the first time that the growth spurt of girls at puberty is strongly associated with the risk of breast cancer in their daughters.'
The study is published online today by the peer-reviewed American Journal of Human Biology.
A woman's chances of contracting breast cancer, the study found, were greater if her mother's "intercristal diameter" - the widest distance between the wing-like structures at the top of the hip bone - was more than 30 centimeters, or 11.8 inches. The risk also was higher if these wing-like structures were also round.
David Barker, professor of medicine (cardiovascular medicine) at OHSU School of Medicine as well as professor of clinical epidemiology at the University of Southampton (UK), is internationally known for discovering the relationship between low birth weight and the lifetime risk for coronary heart disease and other medical disorders, which the British Medical Journal has named the Barker Hypothesis. He has published more than 200 papers and written or edited five books about the developmental origins of chronic disease. He was honored in 2005 with the prestigious Danone International Prize for Nutrition for his pioneering research.
The study published today proposes that breast cancer is initiated in the first trimester of a pregnancy by exposure of the embryo's developing breast tissue to the mother's circulating sex hormones. The primary mammary cord, which gives rise to milk-producing breast lobules, develops in the foetus at 10 weeks. The foetal breast is known to be stimulated by circulating hormones; the intensity of the stimulation is such that half of all newborn babies have breast secretions.
'Our findings support the hypothesis that wide round hips reflect high levels of sex hormone production at puberty, which persist after puberty and adversely affect breast development of the daughters in early gestation,' the authors commented.
They could only speculate, they said, on the exact nature of this adverse effect but pointed out: 'Catechol estrogen, a metabolite of estradiol, is thought to cause chromosomal instability by breaking DNA strands. High catechol estrogen concentrations in the maternal circulation could produce genetic instability in differentiating breast epithelial cells which would make the breast vulnerable to cancer in later life.'
The daughters who were the subjects of the study were all born during 1934-1944 at either Helsinki University Central Hospital or City Maternity Hospital, the two maternity hospitals in Finland's capital. The occurrence of breast cancer among them was ascertained from national registers of all hospital admissions and deaths in Finland. Three hundred of them had had breast cancer of whom 48 died from the disease. Their mean age when they were diagnosed was 54.
The findings shed new light on the link between breast cancer and nutrition. 'Mothers whose daughters developed breast cancer were of similar height to the other mothers,' Barker and Thornburg reported.
'This suggests that they had similar nutrition through childhood. Our findings do not therefore indicate that good nutrition through childhood is linked to breast cancer in the next generation. But they do show that the pubertal growth spurt of girls, which reflects their level of nutrition, is strongly associated with the risk of breast cancer in their daughters.'
The authors of the Journal article besides Barker and Thornburg, who is director of the OHSU Heart Research Center and professor of cardiovascular medicine at the OHSU School of Medicine, were Clive Osmond, senior scientist at the Medical Research Council Epidemiology Resource Centre at the University of Southampton; Eero Kajantie and Tom Forsen, both of Finland's National Public Health Institute; and Johan Eriksson, who holds positions at both the National Public Health Institute as well as with the University of Helsinki's Department of Public Health. Barker and Osmond have collaborated with Eriksson and his Finnish colleagues for the past 12 years tracing some 20,000 men and women in the Helsinki Birth Cohort Study.
Sarah Watts | alfa
Diagnoses: When Are Several Opinions Better Than One?
19.07.2016 | Max-Planck-Institut für Bildungsforschung
High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
25.10.2016 | Earth Sciences
25.10.2016 | Power and Electrical Engineering
25.10.2016 | Process Engineering