The collected research, FHS 100K, is the result of cooperation among several research institutions including Boston University School of Medicine and Public Health; the National Heart, Lung and Blood Institute (NHLBI); the National Library of Medicine; and the National Center for Biotechnology Information (NCBI).
FHS 100K will be given unprecedented availability via BioMed Central's open access journal and through NCBI's Database of Genotypes and Phenotypes (dbGaP) http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007. The researchers' decision to publish in BioMed Central's open access journal underlines their collective belief that genetic observations from FHS should be made publicly available and remain an unpatented data resource designed to accelerate scientific discovery.
"BMC Medical Genetics is honored to be the journal which presents these exciting new results to the world," said Melissa Norton, Editor-in-Chief of BMC Medical Genetics. "Inclusion in both our open access journal and in dbGaP will ensure the widest possible access to these materials and will allow researchers to more easily identify high priority findings for replication to build upon the new findings."
The FHS 100K takes its title from the high resolution 100K Affymetrix GeneChip, designed to contain the genetic sequence array of up 100,000 DNA sequences known as single-nucleotide polymorphisms (SNPs). FHS collaborators studied genetic traits, known as phenotypes, and established 8 larger Phenotype Working Groups, overseeing 17 different trait areas including cardiovascular risk factors and biomarkers; subclinical and clinical cardiovascular disease; cancer and longevity; and pulmonary, sleep, neurology, renal and bone domains. Each research article published in the supplement corresponds with one of these areas.
No other study in history has analyzed as many different phenotypic domains as FHS 100K. In addition, many phenotype samples collected through FHS were gathered years before modern therapy and remain undistorted by the effects of contemporary medical treatments, offering pristine samples unattainable in contemporary subjects.
"The Framingham Heart Study 100K effort was made possible by the generosity of our participants who have received examinations and surveillance for almost 60 years," said Dr. Emelia Benjamin, Professor of Medicine at Boston University School of Medicine (BUSM), and Director of the Echocardiography and Vascular Function laboratories at the Framingham Heart Study
Karen Antman, MD, dean of BUSM and provost of Boston University Medical Campus, added, "The Framingham Heart Study dataset is another example of the groundbreaking collaboration of researchers from Boston University Schools of Medicine and Public Health and from the NHLBI. Our researchers make extraordinary contributions that continuously improve the well-being of people all over the world."
Launched in 1948 by National Heart Institute (now NHLBI), the objective of the Framingham Heart Study is to identify the common factors or characteristics that contribute to cardiovascular disease (CVD) by following its development over a long period of time in a large group of participants who had not yet developed overt symptoms of CVD or suffered a heart attack or stroke. The original researchers recruited 5,209 men and women between the ages of 30 and 62 from the town of Framingham, Massachusetts. Those participants have been followed for nearly 60 years and FHS now includes second and third generation participants.
The data from all of the studies will be made available through NHLBI's dbGaP, a database designed to archive and distribute data from genome wide association studies. Researchers around the world will be able to use the results in the database to conduct further research to create new drugs and treatments to benefit patients. In addition, the results from FHS 100K will automatically be transferred from dbGaP into the SNP Health Association Resource (SHARe) project website, a similar database from NHLBI designed for much larger-scale, whole-genome association study. The SHARe project will analyze 550K SNPs in more than 9,000 samples collected by the NHLBI and Boston University School of Medicine for the Framingham Heart Study.
Charlotte Webber | alfa
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
25.05.2018 | Event News
02.05.2018 | Event News
13.04.2018 | Event News
25.05.2018 | Event News
25.05.2018 | Machine Engineering
25.05.2018 | Life Sciences