Women between the ages of 23 and 60 are regularly called in to submit cell samples. Participating in these check-ups has been shown to provide good protection against cervical cancer. But the test method is not entirely reliable. When a woman develops cervical cancer, the most common reason is that she did not take part in the check-up, but it happens that women who did participate nevertheless get cancer.
Researchers at the Sahlgrenska Academy have carried out a large-scale study comprising 13,484 women in the Göteborg area. Samples were taken at five different maternity clinics. The women were randomly selected to submit cell specimins using either the traditional method or a partially new method. With the new method, liquid-based cytology, the sampler mixes the cells in a fluid solution instead of smearing them on a glass slide. In the laboratory the solution is processed in a machine that produces a glass slide with a purer background that is easier to assess.
In the study, all cell changes found were examined in the same way, regardless of sample type. After the women had been examined using tissue biopsies taken by a gynecologist, between 40 and 60 percent more women with major changes were found in the group that had been sampled using liquid cell specimens. All changes of this degree of severity were then treated with a simple surgical procedure.
"If cell changes in a woman are missed, there are usually further chances of finding them, since these changes develop slowly. But the results of the study indicate that more cases of cancer can be prevented if we start using this more sensitive method," says Björn Strander, a doctoral student at the Sahgrenska Academy who is in charge of preventing cervical cancer at the Oncology Center, Västra Götaland Healthcare Region in western Sweden.
The study also showed that fewer samples had to be thrown out as unassessable, but that the proportion of women who were asked to undergo further examination based on some deviation in their cell specimen rose from 3.5 percent to 4.5 percent of those submitting samples.
¬"Now that we have acquired experience with the method, we see many advantages for the laboratory. The samples are easier to assess, and work goes faster. The remaining fluid can be used for other lab analyses, such as virus testing, which can be a valuable complement in the diagnosis. What's more, part of the diagnosis can be done automatically, a factor that will be important in the future," says Walter Ryd, head of the Cytology Laboratory at the Sahlgrenska University Hospital and leader of the study.
The study is now being published on the Web page of the international scientific journal Cancer Cytopathology.Journal: Cancer Cytopathology
Authors: Björn Strander, Agneta Andersson-Ellström, Ian Milsom, Thomas Rådberg, Walter RydFor more information, please contact:
Doctoral student Björn Strander, Department of Clinical Sciences, cell phone: +46 (0)704-97 22 26, e-mail: email@example.comUlrika Lundin
Ulrika Lundin | idw
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.
The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
29.05.2017 | Earth Sciences
29.05.2017 | Life Sciences
29.05.2017 | Physics and Astronomy