The research, which examined a population of workers at a chemical plant that produced diacetyl (a key component of butter flavoring), was reported in the first issue for September of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.
“Our study found a cluster of [previously undiagnosed] BOS cases in a diacetyl production plant,” said lead author Frits G. B. G. J. van Rooy, M.D., of the Division of Environmental Epidemiology at the Universiteit Utrecht in the Netherlands. “This supports the conclusion that an agent in the diacetyl production process has caused BOS.”
Diacetyl was identified early on as a marker for exposure among popcorn workers. Its specific role, if any, however, in the development of BOS was not known. No cases of BOS had previously been identified outside of North America or in chemical production plants related to flavoring. By investigating the BOS status of former workers of the diacetyl plant, researchers hoped to determine whether there was a link between diacetyl exposure and the development of BOS.
With the help of the human resources department, Dr. van Rooy and colleagues traced 196 former workers who were still living and who had been employed at the diacetyl production plant between 1960 and 2003, when the plant closed. They identified 175 who consented to complete exposure and respiratory health questionnaires and undergo lung function tests and clinical assessments. Of the 102 process workers considered to be at the highest risk for exposure, researchers positively identified three cases of BOS, and later, a fourth, in a worker who had initially declined to participate in the research.
“This is the first study where cases of BOS were found in a chemical plant producing diacetyl,” wrote Dr. van Rooy.
While the researchers were unable to rule out contributions of other chemicals to the development of BOS, the study significantly narrows the field of suspects to diacetyl and the components and byproducts of its manufacturing process.
“The spectrum of exposures is much smaller in this production plant compared with the popcorn processing plants where a wide range of chemicals was identified,” the researchers wrote. “This population-based survey establishes the presence of BOS, or popcorn worker’s lung, in chemical workers manufacturing a flavoring ingredient with exposures to diacetyl, acetoin and acetyldehyde. Any or all of these exposures may contribute to the risk of this emerging occupational disease.”
The novel finding of four cases of BOS in workers at the diacetyl plant has important implications for practicing physicians and public health officials.
“None of the four cases had been recognized as bronchiolitis obliterans or as occupationally related,” wrote Kathleen Kreiss, M.D., in the accompanying editorial in the same issue of the journal. “To identify flavoring-related bronchiolitis obliterans, physicians need to consider the diagnosis,” she noted. Dr. Kreiss, of the Field Studies Branch of the National Institute for Occupational Safety and Health, was one of the first investigators on the scene when “popcorn worker’s lung” arose as a public health issue.
Furthermore, she writes, “the collective evidence for diacetyl causing a respiratory hazard supports action to minimize exposure to diacetyl, even if contributions by other flavoring chemicals exist.”
Suzy Martin | EurekAlert!
Amputees can learn to control a robotic arm with their minds
28.11.2017 | University of Chicago Medical Center
The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
12.12.2017 | Physics and Astronomy
12.12.2017 | Earth Sciences
12.12.2017 | Power and Electrical Engineering