Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mayo Clinic research shows estrogen protects women's brains prior to menopause

30.08.2007
In the largest study of its kind, Mayo Clinic researchers have shown that women who had one or both ovaries removed before menopause faced an increased long-term risk of cognitive impairment or dementia, compared to women who retained their ovaries.

However, women who had both their ovaries removed but were treated with estrogen until at least age 50 did not have any increased risk. The study, which includes follow-up for more that 30 years and interviews with nearly 3,000 women, will appear in the Aug. 29 online edition of Neurology, the medical journal of the American Academy of Neurology.

This research helps clarify questions about the health role of estrogen before the age of natural menopause and estrogen’s ability to protect brain functioning. This study is among the first to provide significant epidemiological evidence supporting the neurological benefits of ovarian preservation in young women and the neuroprotective role of estrogen in younger women.

Significance of the Mayo Clinic Research

“This study is one of the first to obtain large-scale data about neurological diseases in women who had their ovaries removed,” explains Walter Rocca, M.D., Mayo Clinic neurologist, epidemiologist and lead author of the study. “Our findings will contribute to a better understanding of the advantages and disadvantages of removing the ovaries in young women. In addition, our findings suggest that there is a window of therapeutic opportunity for prescribing estrogen replacement therapy in women who undergo ovary removal before age 50. This window of opportunity is before the approximate age of naturally occurring menopause, when the benefits of neuroprotection are likely to outweigh the risks of side effects of estrogen therapy.” By contrast, other studies have shown that when estrogen treatment is started after age 60 to 65, the risk of heart problems, stroke and cognitive impairment or dementia is increased.

Research results also showed that the risk for cognitive impairment or dementia increased the younger the woman was at ovary removal. “Adverse results increased for women who were of a younger age at surgery, and were the same regardless of reason for ovary removal. Somewhat more surprising, cognitive impairment was observed even in women who had only one ovary removed,” explains Dr. Rocca.

Implications for Patient Care

The study may have important medical implications for women facing choices about ovary removal and estrogen treatment after the surgery.

“In every medical or surgical decision there is a trade-off between risks and benefits,” says Bobbie Gostout, M.D., a Mayo Clinic gynecological and obstetrical surgeon. “Therefore, a woman considering ovary removal should discuss these findings with her physician prior to the surgery to consider the long-term implications and the possible strategies for estrogen treatment following the surgery.

“In view of this new information, careful individualized counseling is necessary to help women make informed decisions. When oophorectomy (ovary removal) is indicated in a young woman, it is important to carefully educate that patient regarding estrogen replacement. Unless clear contraindications are present, most women should be advised to take estrogen therapy until approximately age 50,” explains Dr. Gostout.

About the Study

Mayo Clinic is home to the Rochester Epidemiology Project, which collects medical records beginning in 1935, and is now one of the largest long-term integrated databases of patient records in the world. The Mayo Clinic team used the system to identify all the women in Olmsted County, Minn., who had one or both ovaries removed -- 1,489 women -- between 1950 and 1987.

These women were matched by age with an equal number of women who did not have ovarian surgery (1,472). Researchers then interviewed women in both groups (or their relatives) and compared the risk of cognitive impairment or dementia between the two groups, until the time of death. Women who were alive were interviewed in person and underwent a cognitive test over the telephone. For women who had died, a family member was interviewed.

Carol Lammers | EurekAlert!
Further information:
http://www.mayo.edu
http://www.mayoclinic.com
http://www.mayoclinic.org/news

More articles from Studies and Analyses:

nachricht Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>