Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mayo Clinic research shows estrogen protects women's brains prior to menopause

30.08.2007
In the largest study of its kind, Mayo Clinic researchers have shown that women who had one or both ovaries removed before menopause faced an increased long-term risk of cognitive impairment or dementia, compared to women who retained their ovaries.

However, women who had both their ovaries removed but were treated with estrogen until at least age 50 did not have any increased risk. The study, which includes follow-up for more that 30 years and interviews with nearly 3,000 women, will appear in the Aug. 29 online edition of Neurology, the medical journal of the American Academy of Neurology.

This research helps clarify questions about the health role of estrogen before the age of natural menopause and estrogen’s ability to protect brain functioning. This study is among the first to provide significant epidemiological evidence supporting the neurological benefits of ovarian preservation in young women and the neuroprotective role of estrogen in younger women.

Significance of the Mayo Clinic Research

“This study is one of the first to obtain large-scale data about neurological diseases in women who had their ovaries removed,” explains Walter Rocca, M.D., Mayo Clinic neurologist, epidemiologist and lead author of the study. “Our findings will contribute to a better understanding of the advantages and disadvantages of removing the ovaries in young women. In addition, our findings suggest that there is a window of therapeutic opportunity for prescribing estrogen replacement therapy in women who undergo ovary removal before age 50. This window of opportunity is before the approximate age of naturally occurring menopause, when the benefits of neuroprotection are likely to outweigh the risks of side effects of estrogen therapy.” By contrast, other studies have shown that when estrogen treatment is started after age 60 to 65, the risk of heart problems, stroke and cognitive impairment or dementia is increased.

Research results also showed that the risk for cognitive impairment or dementia increased the younger the woman was at ovary removal. “Adverse results increased for women who were of a younger age at surgery, and were the same regardless of reason for ovary removal. Somewhat more surprising, cognitive impairment was observed even in women who had only one ovary removed,” explains Dr. Rocca.

Implications for Patient Care

The study may have important medical implications for women facing choices about ovary removal and estrogen treatment after the surgery.

“In every medical or surgical decision there is a trade-off between risks and benefits,” says Bobbie Gostout, M.D., a Mayo Clinic gynecological and obstetrical surgeon. “Therefore, a woman considering ovary removal should discuss these findings with her physician prior to the surgery to consider the long-term implications and the possible strategies for estrogen treatment following the surgery.

“In view of this new information, careful individualized counseling is necessary to help women make informed decisions. When oophorectomy (ovary removal) is indicated in a young woman, it is important to carefully educate that patient regarding estrogen replacement. Unless clear contraindications are present, most women should be advised to take estrogen therapy until approximately age 50,” explains Dr. Gostout.

About the Study

Mayo Clinic is home to the Rochester Epidemiology Project, which collects medical records beginning in 1935, and is now one of the largest long-term integrated databases of patient records in the world. The Mayo Clinic team used the system to identify all the women in Olmsted County, Minn., who had one or both ovaries removed -- 1,489 women -- between 1950 and 1987.

These women were matched by age with an equal number of women who did not have ovarian surgery (1,472). Researchers then interviewed women in both groups (or their relatives) and compared the risk of cognitive impairment or dementia between the two groups, until the time of death. Women who were alive were interviewed in person and underwent a cognitive test over the telephone. For women who had died, a family member was interviewed.

Carol Lammers | EurekAlert!
Further information:
http://www.mayo.edu
http://www.mayoclinic.com
http://www.mayoclinic.org/news

More articles from Studies and Analyses:

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>