Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Facial Transplantation May Be a Safer Option

29.08.2007
Researchers in Cincinnati and Louisville report that immunosuppressive risks associated with facial transplantation may be lower than thought, possibly making the procedure a safer option for people who have suffered severe facial injuries.

Previous data on the immunosuppression risks involved in facial transplantation were misleading, according to Rita Alloway, PharmD, and Steve Woodle, MD, of the University of Cincinnati (UC), and a University of Louisville team led by John Barker, MD, PhD. Their findings appear in the September edition of the journal Plastic and Reconstructive Surgery.

The first recorded facial transplant was performed in France in 2005 on a 38-year-old woman whose nose, lips and chin had been bitten off by a dog. Tissues, muscles, arteries and veins were taken from a brain-dead donor and successfully transplanted to the patient’s lower face.

There have been only two similar attempts since.

In 2004, the British Royal College of Surgeons published a controversial report predicting a high incidence of immunological complications for facial transplants. This data became a benchmark for facial transplant teams and review boards and greatly influenced the facial transplantation debate.

According to Woodle, however, the report did not provide the best risk assessment.

”In estimating the risks of immunosuppression for face transplant recipients, the biggest problem is comparing apples to oranges,” Woodle says. “What we have tried to do is to address the apples and oranges problem by a comprehensive and up-to-date consideration of the issue.”

Both the health status of solid organ transplant recipients and the tissue composition of the solid organs reported in the earlier studies are very different from that of face transplant recipients and their facial tissues, he says.

In the current study, the Cincinnati and Louisville researchers compared the 2004 data with that taken from clinical studies describing kidney and hand transplants using the latest immunosuppression techniques.

They found the outcomes to be very different from those in the 2004 study.

Based on kidney and hand transplantation cases, in which the same drug regimen was used, researchers found that acute, or immediate, rejection may occur in 10 to 70 percent of patients. In of all these cases, however, rejection was reversible by adjusting the immunosuppression medications.

They also found that fewer than 10 percent of patients would experience chronic rejection over five years.

“In considering the most recent and relevant data, we came to the conclusion that the expectations for face transplant recipients should be significantly better than those previously published,” Woodle says.

Coauthor Barker says that the lack of comparable “apples-to-apples” risk data in the field has led to debate over the ethics of face transplantation, which was the inspiration for Cincinnati-Louisville study.

“This risk-benefit equation is at the center of controversy over facial transplantation,” he says. “Physicians and scientists question whether the risks of life-long immunosuppression for patients justify the benefits of this new treatment.”

Cincinnati coauthor Alloway says that physicians often don’t realize how much patients will endure to gain relief.

“Surveys from transplant professionals have shown that doctors underestimate what people will do for a cure,” Alloway says. “Often, living disfigured is worse than risk associated with this sort of operation and the immunosuppressive risks that accompany it.”

Researchers hope this study will provide a solid foundation for future work with facial transplantation.

“We’re trying to meld the fields of transplantation and immunosuppression to produce maximum expertise on the subject,” Alloway continued. “We’re hoping to decrease toxicity and create a more manageable risk spectrum for surgeons and patients.”

Other coauthors on the study were Allen Furr, PhD, Joseph Banis, Jr., MD, Rachael Ashcroft, and Dalidor Vasilic, MD, from the University of Louisville as well as and Moshe Kon, MD, PhD, from the University of Utrecht, Netherlands.

Katie Pence | EurekAlert!
Further information:
http://www.uc.edu

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Positrons as a new tool for lithium ion battery research: Holes in the electrode

22.02.2017 | Power and Electrical Engineering

New insights into the information processing of motor neurons

22.02.2017 | Life Sciences

Healthy Hiking in Smart Socks

22.02.2017 | Innovative Products

VideoLinks
B2B-VideoLinks
More VideoLinks >>>