That is the conclusion of Professor Harry Bartelink, from the Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital (NKI-AVL) in Amsterdam, and his colleagues in the August issue of the top oncology journal Journal of Clinical Oncology.
During this randomized study, more than 5000 breast cancer patients were followed for 10 years. The research is a collaboration between the NKI-AVL and 32 other European research institutes, lead by Professor Harry Bartelink.
In the Netherlands, about 1 in 9 women get breast cancer. Breast cancer is therefore the most common cancer in women. Approximately 80% of the women are treated with breast conserving surgery.
Professor Harry Bartelink and his colleagues followed breast cancer patients who received two doses of irradiation after surgery: a dose of 50 Gy, followed by an extra “boost” dose of 16 Gy. The boost dose lead to a 40% reduction in the chance of tumor recurrence after breast conserving surgery. The largest gain was shown for young women with breast cancer. Another important point is that with this treatment more than 80% of the patients are alive at 10 years after treatment.
Bartelink: “The favourable treatment results are partly due to the strict quality control that the participating centers had to adhere to. The outcome of this trial has lead to a worldwide change in the treatment policy for women with breast cancer”.
In a new Dutch collaboration the Professor of Radiotherapy has started a large study where he hopes to further improve the treatment results for young women with breast cancer. At the same time, ways to use modern molecular techniques for predicting sensitivity to radiation are being investigated.
Frederique Melman | alfa
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Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
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