"Lithium is the prototype mood stabilizer for treating adult bipolar disorder, but it is not FDA-approved for use in kids younger than 13," said Mani Pavuluri, director of the Pediatric Mood Disorders Clinic at UIC's Institute for Juvenile Research. "We do not have a perfect drug that cures all aspects of bipolar disorder, but knowing more about lithium -- and how it affects children -- may bring us closer to managing this devastating disorder."
Results from the Collaborative Lithium Trials will provide the first comprehensive analysis of lithium treatment for pediatric bipolar disorder, according to Pavuluri.
UIC researchers are recruiting patients between 7 and 17 with bipolar disorder. The study will evaluate medication dosage strategies, drug efficacy, and short- and long-term safety and tolerability.
Pediatric bipolar disorder, also known as manic depressive disorder, is characterized by extreme and unusual changes in mood, ranging from mania to depression. Symptoms of mania can include extreme or persistent euphoria or irritability, inflated self-esteem, increased energy and a decreased need for sleep. Depressive symptoms may include physical complaints such as headaches, tiredness, lack of interest in activities, or social isolation.
In children, the disorder interferes with normal, healthy functioning and is associated with suicide, school failure, and risk-taking behaviors such as sexual promiscuity and substance abuse.
The prevalence and incidence of pediatric bipolar disorder is unknown.
"Lithium has proven to be effective in preventing future episodes of bipolar disorder and reducing suicidal thoughts in adults," said Pavuluri, who leads the UIC trial. "This study will help us to determine if lithium may have a similar protective effect in pediatric patients and help us to develop future treatment protocols."
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Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
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A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
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Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).
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