"Lithium is the prototype mood stabilizer for treating adult bipolar disorder, but it is not FDA-approved for use in kids younger than 13," said Mani Pavuluri, director of the Pediatric Mood Disorders Clinic at UIC's Institute for Juvenile Research. "We do not have a perfect drug that cures all aspects of bipolar disorder, but knowing more about lithium -- and how it affects children -- may bring us closer to managing this devastating disorder."
Results from the Collaborative Lithium Trials will provide the first comprehensive analysis of lithium treatment for pediatric bipolar disorder, according to Pavuluri.
UIC researchers are recruiting patients between 7 and 17 with bipolar disorder. The study will evaluate medication dosage strategies, drug efficacy, and short- and long-term safety and tolerability.
Pediatric bipolar disorder, also known as manic depressive disorder, is characterized by extreme and unusual changes in mood, ranging from mania to depression. Symptoms of mania can include extreme or persistent euphoria or irritability, inflated self-esteem, increased energy and a decreased need for sleep. Depressive symptoms may include physical complaints such as headaches, tiredness, lack of interest in activities, or social isolation.
In children, the disorder interferes with normal, healthy functioning and is associated with suicide, school failure, and risk-taking behaviors such as sexual promiscuity and substance abuse.
The prevalence and incidence of pediatric bipolar disorder is unknown.
"Lithium has proven to be effective in preventing future episodes of bipolar disorder and reducing suicidal thoughts in adults," said Pavuluri, who leads the UIC trial. "This study will help us to determine if lithium may have a similar protective effect in pediatric patients and help us to develop future treatment protocols."
Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland
Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Materials Sciences
29.03.2017 | Physics and Astronomy
29.03.2017 | Earth Sciences