As in the previous prostate cancer study, which was also conducted by USC researchers and published in the April 2007 edition of Nature Genetics, the colorectal cancer risk factor is located in a region of the human genome devoid of known genes on chromosome 8. The study’s complete findings will be published in the July 8 online edition of Nature Genetics.
“This is an important finding because, for the first time, a common genetic risk factor for multiple cancers has been identified,” says lead author Christopher Haiman, assistant professor of preventive medicine at the Keck School of Medicine of USC. Adding, “There appears to be something fundamental occurring in this region that influences not only colorectal and prostate cancer, but perhaps cancers in general.” (Another recently published study, in which USC researchers also were involved, identified variants in this same chromosomal region as playing a predictive role relative to the risk of developing breast cancer.)
For the current colorectal cancer study, the USC team genotyped six of the seven variants previously identified as increasing the risk of prostate cancer development. The samples analyzed totaled 1,807 invasive colorectal cancer cases and 5,511 controls. These samples were drawn from five populations (African Americans, Japanese Americans, Native Hawaiians, Latinos, and European Americans) included in the Multiethnic Cohort Study, an epidemiological study of more than 215,000 people from Los Angeles and Hawaii created in 1993 by Brian Henderson, dean, Keck School of Medicine of USC, and Laurence Kolonel of the University of Hawaii.
According to Henderson, co-author of the colorectal cancer study, “Having previously identified several genetic risk factors related to prostate cancer, and now having identified one of these same variants as predictive of colorectal cancer risk, brings us closer to our long-term goal of developing a model that more precisely pinpoints who is at greater risk for developing colorectal, prostate, and other cancers.” However, Henderson notes, “We still need to identify the biological mechanism through which these variants are influencing the development of various cancers.”
Jennifer Chan | EurekAlert!
Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland
Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
27.03.2017 | Health and Medicine
27.03.2017 | Life Sciences
27.03.2017 | Earth Sciences