Results from the clinical trial demonstrated that the compound colesevelam HCl, in combination with Sulfonylurea-based therapy in patients with inadequately controlled type 2 diabetes, achieved significantly reduced glucose levels versus those in the study taking a placebo. The study was recently presented at the American Association of Clinical Endocrinologists’ 16th Annual Meeting and Clinical Congress.
“People with uncontrolled type 2 diabetes and high cholesterol face a number of challenges in keeping their glucose levels and cholesterol in check. This study demonstrated the potential to improve two important metabolic parameters with one drug,” says Fonseca.
Patients who received colesevelam HCl were shown in the study to have significant reductions in blood sugar levels, and participants’ lipid profiles in the colesevelam HCl group also showed substantial improvement over placebo. An application for the commercial production and sale of the drug is currently being assessed by the U. S. Food and Drug Administration.
The American Diabetes Association estimates that 20.8 million people in the United States have diabetes and over 90 percent of these have type 2 diabetes. The Association recommends that these patients control their glucose levels, keeping their blood sugar level at less than 7 percent. The National Cholesterol Education Program recommends that patients with type 2 diabetes keep their cholesterol levels in check and target a goal of less than 100 mg/dL for “bad cholesterol” levels in the blood.
Arthur Nead | EurekAlert!
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Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
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A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
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