As some clinical studies had already outlined, stress is one of the most important causes of relapse observed in abstinent smokers. The study has revealed, in genetically-modified animals, that there is effectively a genetic predisposition to suffer more or less sensitivity to stress, and that this circumstance is capable of significantly modifying behaviour patterns, to the extent of inducing relapse in the craving for nicotine.
The study findings are included in the project “Vulnerability to nicotine addiction” which began in late 2004 and has the support of the National Institute on Drug Abuse (NIDA), part of the United States National Institutes of Health (NIH), that granted Rafael Maldonado one and a half million dollars (approximately 1,172,000 euros) to direct this ambitious project which has the participation of other European research groups, all of which are coordinated from the UPF.
Through the use of sophisticated genomic and behavioural analytical methods, the study has evaluated not only physical nicotine dependency but also affective manifestations and changes in behaviour caused by its presence in the body, such as states of anxiety, the craving to smoke or relapses after long periods of abstinence - this being one of the most innovative aspects of the study.
One of the aims of this project is to identify the neurobiological substrate underlying differences in individual vulnerability to nicotine addiction. Studies in genetically-modified mice show how nicotine affects the endogenous opiate system, the function of which in all mammals is to alleviate pain, increase positive emotions and provide pleasurable feelings. In short, the aim is to know more about the mechanisms involved in nicotine addiction that make us more prone to the habit of smoking.
Núria Pérez-Pérez | alfa
New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg
Disarray in the brain
18.12.2017 | Universität zu Lübeck
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
18.01.2018 | Life Sciences
18.01.2018 | Life Sciences
18.01.2018 | Earth Sciences