Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study could impact noninvasive treatment of cancer tumors

18.06.2007
LSU researchers investigate the effects of nanoparticles on cell freezing

Ram Devireddy, assistant professor of mechanical engineering at LSU, recently co-authored an article with Todd Monroe, assistant professor of biological and agricultural engineering, investigating the complex effects of nanoparticles on cell freezing. The report was published in the prestigious journal Nanotechnology.

The results of their study – while not what they expected – could end up impacting cancer treatment. Devireddy and Monroe initiated a study to investigate the effects of gold-based nanoparticles, or microscopic particles equal to one-thousandth the thickness of a single strand of human hair, on cell transport and the response of those cells after being frozen. Their hypothesis: nanoparticles would alleviate the damaging effects generally caused by the freezing process.

“Most cells are like bags of water,” Devireddy said. “Ice crystals have sharp edges that tend to poke the cells and break them up, causing damage. That is why, for example, frozen food, when thawed and cooked, tends to be ‘mushier’ that fresh produce.”

The researchers, along with graduate students Sreedhar Thirumala and Julianne Audiffred, used the nanoparticles to replace dimethylsulfoxide, a commonly used cryoprotective agent.

“Cryoprotective agents, or CPAs, have long been used to alleviate freezing injury and to enhance the number of cells that survive the freezing process,” said Thirumala. The drawback is that CPAs can also cause cell death when used in high concentrations and need to be removed from cells immediately after freezing.

Devireddy and Monroe believed that nanoparticles might act as a benign replacement for CPAs. To test this, they added commercially available gold nanoparticles to cells suspended in a culture medium.

However, contrary to their initial hypothesis, Devireddy and Monroe found that the nanoparticles did not significantly change the freezing response of either HeLa cells, which are derived from a specific cervical cancer cell line, or Jurkat cells, cancer cells commonly used in research due to their abnormally rapid growth rate in lab conditions.

While test results showed that the nanoparticles were not as effective in protecting frozen cells as the more traditional CPAs, there was significant damaging interaction between the nanoparticles and both HeLa and Jurkat cells, suggesting the need for more research.

Potential practical applications for such research includes improved cryosurgical procedures, which are non-invasive procedures used to eradicate cancer tumors inside the body by cooling them to extremely low temperatures.

Both Devireddy and Monroe plan to pursue this project, citing their teamwork as a driving factor in the effectiveness of their research and teaching.

“The benefit of having each other to ‘cross-train’ our students also better prepares them for future careers in bioengineering research,” said Monroe.

Ram Devireddy | EurekAlert!
Further information:
http://www.lsu.edu

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>