Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study assesses lung treatments for premature babies

09.05.2007
A pig-derived surfactant given to premature babies whose lungs aren’t yet making the lubricant reduces mortality rates by 19 percent over two other commercially-available surfactants, researchers say.

A retrospective study of 24,883 premature babies with respiratory distress syndrome treated in 191 U.S. hospitals from January 2003 to June 2006 showed reduced mortality for all causes in babies given poractant alfa, according to lead researcher Dr. Jatinder Bhatia, chief of the Section of Neonatology at the Medical College of Georgia in Augusta. “The differences hold true whether you are sitting in a rural hospital or teaching hospital or non-teaching hospital.”

The study was the first to compare all three natural surfactants used in this country to treat babies with respiratory distress syndrome. Previous studies, comparing poractant alfa with calf-derived beractant, have yielded similar results; studies comparing beractant and calfactant, also calf-derived, demonstrated no differences in mortality. The smaller studies prompted researchers to do their more comprehensive review.

Their results are being presented May 7 during the Pediatric Academic Societies Annual Meeting in Toronto.

“We are looking at a large, vulnerable population and we need this kind of data to make informed decisions,” Dr. Bhatia says. He notes that the current analysis doesn’t explain differences in mortality so additional studies might be needed.

About 12.7 percent of babies are born prematurely in the United States annually and about 30,000-40,000 babies have respiratory distress with surfactant deficiency.

“It’s inversely related to gestational age and birth weight: the younger the baby, the higher the percentage of these babies that have little or no surfactant,” says Dr. Bhatia.

Surfactant is a viscous, soapy-like substance that keeps thousands of air sacs inside the lungs from sticking together when they inflate and deflate while breathing. “If you think of the lungs as a million little balloons, these balloons collapse when the baby tries to breathe out and that is why they get into respiratory distress,” says Dr. Bhatia.

Premature lungs don’t immediately produce the essential lubricant, and air sacs are quickly damaged trying to function without it, even with ventilator support.

Neonatologists try to prevent damage by giving surfactant within the first hour after birth to tide the baby over until his own lungs start producing it some 48 hours later, Dr. Bhatia says. Prescribed surfactant will eventually become part of the baby’s endogenous pool.

“We can give surfactant of a similar composition as Mother Nature would have made to help ameliorate the disease process. The basic premise is to give surfactant as early as possible to prevent the baby’s lungs from collapsing. Once they collapse, it takes greater support from the outside to reopen these units,” Dr. Bhatia says.

The surfactant effect is almost instantaneous. In fact, neonatologists are increasingly taking babies off the ventilator at the same time surfactant is given. Prenatal steroids, which accelerate lung maturity, are given to mothers when premature birth is imminent. Lung-sparing measures, such as the lowest possible ventilator setting, also are used.

Pig-derived poractant alfa, a relative newcomer approved by the FDA in 1999, was the least-used surfactant in the study population. Of the 24,883 babies in the data base provided by Charlotte, N.C.-based Premier Inc. 4,953 got poractant alfa, marketed as Curosurf®; 12,653 got beractant marketed as Survanta®; and 7,277 got calfactant, marketed as Infasurf®.

Co-authors on the study included researchers at Women’s and Children’s Hospital in Los Angeles and the University of Oklahoma Health Sciences Center in Oklahoma City.

The study was funded by Dey, L.P. and Chiesi Farmaceutici of Parma, Italy, which market and make poractant alfa. None of the researchers have financial interests in either company.

Toni Baker | EurekAlert!
Further information:
http://www.mcg.edu

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>