Previous studies have suggested a link between HRT use and breast cancer. Ahmedin Jemal and colleagues at the American Cancer Society conducted statistical analysis to examine patterns in invasive and in situ breast cancer incidence in relation to age, tumour size at diagnosis and disease stage. Regular mammography screening starts at 40 and HRT is most common in women aged 50 or older, so the study focussed on women age 40 and above.
The research team examined trends in breast cancer incidence in the National Cancer Institute’s Surveillance Epidemiology and End Results database from 1975 to 2003. The database includes women from 5 US States (Connecticut, Hawaii, Iowa, New Mexico, and Utah) and 5 metropolitan cities (Atlanta, Detroit, San-Francisco, and Seattle). Almost 400,000 invasive and 60,000 in situ cases of breast cancer were diagnosed in that time. Breast cancer incidence rates increased by almost 40% between 1980 and 1998, and then showed a downward trend with a dramatic decrease from 2002 to 2003. The greatest decline was in women who had small tumours, early stage disease, estrogen/progestin positive tumours, and who were aged 55 or older.
Jemal et al concluded that the speed of decrease in breast cancer incidence, following the dramatic reduction in HRT use after the Women’s Health initiative publication in 2002, likely reflects the early consequences of reductions in HRT use, while the downturn in incidence rates across multiple age groups beginning 1998/1999 reflects the saturation of mammography.
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
New study from the University of Halle: How climate change alters plant growth
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A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
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A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
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Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
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23.02.2018 | Physics and Astronomy