Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Ibuprofen and other popular painkillers may increase the risk of heart attack

Research from The University of Nottingham showing that Ibuprofen and other popular painkillers may increase the risk of heart attack was the British Medical Journal’s (BMJ) most widely read paper in 2005.

The study, the biggest of its kind, was led by Professor Julia Hippisley-Cox in the University’s Division of Primary Care. It looked at prescribing patterns for over 9,000 patients aged between 25 and 100 across England, Scotland and Wales. The data came from the QRESEARCH database, run by the University in collaboration with the leading IT software provider EMIS. The online version of the BMJ paper was accessed 42,505 times in the first year after publication. It received 28 rapid responses and was cited 97 times in 2005 and 2006.

At the time there was widespread interest in the cardiovascular safety of COX 2 inhibitors after the withdrawal of Vioxx and several papers were published on the risk associated with these agents. The results have since been replicated in other countries by other academic teams.

Trish Groves, Deputy and Senior Research Editor at the BMJ, said: “Most of the papers in the top 10 provided important new evidence on highly controversial questions that mattered then to patients — and still do”. Several were about the safety and effectiveness of widely used treatments for common conditions, she noted. “These studies provide a broader kind of evidence: by systematically reviewing and summarising the best data out there, or analysing what really happened to large numbers of people in real life over time.”

Professor Julia Hippisley-Cox said “This is excellent news not least for the many thousands of GPs who have contributed to QRESEARCH by freely sharing their data to be used for medical research. We will continue to pioneer research into the real risks and benefits for treatments in primary care to give GPs the best information to improve clinical care for the individual patient.”

Dr David Stables, clinical director of EMIS, said “The ethical and non-commercial use of information makes QRESEARCH a worthwhile project that can make a significant difference to healthcare. We are very grateful to the practices who continue to take part in this project“

The study found that for those prescribed NSAIDS in the three months before the heart attack, the risk increased compared with those who had not taken these drugs in the previous three years. For ibruprofen, the risk increased by almost a quarter (24 per cent) and for diclofenac it rose by more than half (55 per cent)

The newer generation of painkillers — COX-2 inhibitors — were also associated with the increased rates of first-time heart attack. Those prescribed the drugs in the proceeding three months were at 21 per cent higher risk of heart attack if taking celecoxib, and 32 per cent increased risk if taking rofecoxib.

Emma Thorne | alfa
Further information:

More articles from Studies and Analyses:

nachricht Diagnoses: When Are Several Opinions Better Than One?
19.07.2016 | Max-Planck-Institut für Bildungsforschung

nachricht High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>