In the study, funded by the UK's Wellcome Trust, researchers at the Africa Centre, University of KwaZulu-Natal, found that there was a 4% risk of postnatal transmission to infants solely fed on breast milk between the age of 6 weeks and 6 months of age. Infants who received formula milk or animal milk in addition to breast milk were nearly twice as likely to be infected as infants who received breast milk only. More alarmingly, those given solids in addition to breast milk were almost eleven times more likely to acquire infection.
"The question of whether or not to breastfeed is not a straightforward one," says Professor Hoosen Coovadia from the Africa Centre. "We know that breastfeeding carries with it a risk of transmitting HIV infection from mother to child, but breastfeeding remains a key intervention to reduce mortality. In many areas of Africa where poverty is endemic, replacement feed, such as formula milk or animal milk, is expensive and cannot act as a complete substitute. The key is to find ways of making breastfeeding safe."
In the developed world, the risk of transmission of HIV from mother to child has been dramatically reduced from about 25% to less than 2% thanks to the use of antiretroviral therapies, exclusive formula feeding regimes and excellent healthcare systems, but these are not available in resource-poor areas.
The mucous membrane within the intestine is thought to act as an effective barrier to HIV infection. Breast milk ordinarily strengthens and protects this lining. Exclusive breastfeeding is also associated with fewer breast health problems such as mastitis and breast abscesses, both of which can increase the amount of the HIV virus in the mother's breastmilk. It is unclear why adding solids may be particularly hazardous, though previous research has suggested that the larger, more complex proteins found in solid foods may lead to greater damage to the lining of the stomach, allowing the virus to pass through the gut wall.
Professor Coovadia and colleagues also found a significant increase in the risk of transmission even amongst exclusively breastfed infants when the mother had a CD4 cell count of less than 200/ml. CD4 cells coordinate the immune systems response to infection. Compared to mothers with a CD4 cell count of 500/ml, mothers with a CD4 count of less than 200/ml were almost twice as likely to infect their infants.
In addition to studying the risks of transmission, trained lay workers offered counselling to HIV-infected mothers to improve exclusive breastfeeding practices. As a result, they were able to achieve a much higher rate of exclusive breastfeeding than previously reported in similar communities.
The validity and importance of the results have been strengthened by other recently published and ongoing studies in Africa which confirm the team's findings about reduced transmission of HIV with exclusive breastfeeding, and the dangers to infant health and survival when replacement feeding deprives babies of the protective shield of breast milk.
"Based on our findings and evidence of being able to successfully support exclusive breastfeeding in HIV-infected women, and recent data from other parts of Africa, we believe that current guidelines on infant feeding warrant revising," says Professor Coovadia. "Previous reports have confused rather than guided such policies and we hope that our study will help clarify this complex issue."
Craig Brierley | alfa
The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig
Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
17.11.2017 | Physics and Astronomy
17.11.2017 | Health and Medicine
17.11.2017 | Studies and Analyses