New findings by a Queen's University research team dispel the popular notion that eating so-called "natural" foods will protect against cancer.
In fact, certain types of common foods and alcoholic beverages such as wine, cheese, yogurt and bread contain trace amounts of carcinogens. Maintaining a balanced diet from a variety of sources – including garlic – is a better choice, the researchers suggest.
Led by Dr. Poh-Gek Forkert of Queen's Department of Anatomy and Cell Biology, the team has discovered that a naturally-occurring carcinogen found in alcoholic beverages and fermented foods causes DNA modification and mutations, ultimately leading to abnormal cell growth and lung cancer. Her research also shows that a component of garlic significantly reduces these changes.
The most recent Queen's findings are published on-line today in the journal, Carcinogenesis. This is the third in a series of four related papers: two of the companion papers are published on-line in the International Journal of Cancer and Drug Metabolism and Disposition.
Dr. Forkert's team includes PhD student Lya Hernandez and postdoctoral fellows, Drs. Heidi Chen and Ashish Sharma (all from Anatomy and Cell Biology). Also collaborating on the team are PhD student Martin Kaufmann (Biochemistry), Dr. Glenville Jones (Biochemistry), and Dr. Raymond Bowers (Chemistry).
The researchers are studying the effects of treatment with vinyl carbamate in mice. This substance is derived from ethyl carbamate (urethane), a by-product of fermentation found in alcoholic beverages, and fermented foods like cheese, yogurt and bread. It is also present naturally in tobacco.
Now labeled as a potential human carcinogen by both the World Health Organization and the International Agency for Research on Cancer, urethane was given inadvertently to millions of patients in Japan, between 1950 and 1975, in analgesic and sedative drugs. It was estimated that the total dose of urethane administered to a 60-kilogram patient was about 0.6 to 3.0 grams. This is believed to be the largest dose on record of a pure carcinogen administered directly to people.
In 1985, Health and Welfare Canada placed limits on urethane contained in Canadian (but not imported) alcoholic beverages. "The problem is how to regulate the levels in imported goods," says Dr. Forkert.
In these studies, the mice were administered a single high dose of the carcinogenic chemical. Human exposure differs from that in mice in that it is much lower, and occurs over a prolonged period of time. A question has been raised regarding the effect on people who ingest low levels of the chemical daily over many years, and perhaps over a lifetime.
"We believe that people should not be apprehensive about consuming these foods and beverages: if consumed at low levels, they probably don't pose a risk. It might be prudent, however, to have a varied diet and to limit drinking certain alcoholic beverages," says Dr. Forkert. "And include garlic!" she adds.
Nancy Dorrance | EurekAlert!
Obstructing the ‘inner eye’
07.07.2017 | Friedrich-Schiller-Universität Jena
Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
21.07.2017 | Event News
19.07.2017 | Event News
12.07.2017 | Event News
21.07.2017 | Earth Sciences
21.07.2017 | Power and Electrical Engineering
21.07.2017 | Physics and Astronomy