New findings by a Queen's University research team dispel the popular notion that eating so-called "natural" foods will protect against cancer.
In fact, certain types of common foods and alcoholic beverages such as wine, cheese, yogurt and bread contain trace amounts of carcinogens. Maintaining a balanced diet from a variety of sources – including garlic – is a better choice, the researchers suggest.
Led by Dr. Poh-Gek Forkert of Queen's Department of Anatomy and Cell Biology, the team has discovered that a naturally-occurring carcinogen found in alcoholic beverages and fermented foods causes DNA modification and mutations, ultimately leading to abnormal cell growth and lung cancer. Her research also shows that a component of garlic significantly reduces these changes.
The most recent Queen's findings are published on-line today in the journal, Carcinogenesis. This is the third in a series of four related papers: two of the companion papers are published on-line in the International Journal of Cancer and Drug Metabolism and Disposition.
Dr. Forkert's team includes PhD student Lya Hernandez and postdoctoral fellows, Drs. Heidi Chen and Ashish Sharma (all from Anatomy and Cell Biology). Also collaborating on the team are PhD student Martin Kaufmann (Biochemistry), Dr. Glenville Jones (Biochemistry), and Dr. Raymond Bowers (Chemistry).
The researchers are studying the effects of treatment with vinyl carbamate in mice. This substance is derived from ethyl carbamate (urethane), a by-product of fermentation found in alcoholic beverages, and fermented foods like cheese, yogurt and bread. It is also present naturally in tobacco.
Now labeled as a potential human carcinogen by both the World Health Organization and the International Agency for Research on Cancer, urethane was given inadvertently to millions of patients in Japan, between 1950 and 1975, in analgesic and sedative drugs. It was estimated that the total dose of urethane administered to a 60-kilogram patient was about 0.6 to 3.0 grams. This is believed to be the largest dose on record of a pure carcinogen administered directly to people.
In 1985, Health and Welfare Canada placed limits on urethane contained in Canadian (but not imported) alcoholic beverages. "The problem is how to regulate the levels in imported goods," says Dr. Forkert.
In these studies, the mice were administered a single high dose of the carcinogenic chemical. Human exposure differs from that in mice in that it is much lower, and occurs over a prolonged period of time. A question has been raised regarding the effect on people who ingest low levels of the chemical daily over many years, and perhaps over a lifetime.
"We believe that people should not be apprehensive about consuming these foods and beverages: if consumed at low levels, they probably don't pose a risk. It might be prudent, however, to have a varied diet and to limit drinking certain alcoholic beverages," says Dr. Forkert. "And include garlic!" she adds.
Nancy Dorrance | EurekAlert!
Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland
Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
23.03.2017 | Life Sciences
23.03.2017 | Power and Electrical Engineering
23.03.2017 | Earth Sciences