The new method, developed by Professor Jarl Wikberg at Uppsala University, allowed the researchers to create a ‘map’ that in detail shows how 61 drug targets from nine different retroviruses interact with surrounding molecules.
The problem in HIV is that the virus mutates very easily. This leads to appearance of new strains that escape the body’s immune defence as well as drug retardants. The virus becomes resistant to the retardant and the treatment fails.
“This is a large problem. Resistant strains appear gradually in all patients irrespectively which combinations of the present treatments are used. Finally there is no alternative to treat the patient”, says Jarl Wikberg.
The new method – proteochemometrics – makes it possible to predict how effectively drug candidates will retard different HIV-strains. This makes it a relatively simple matter to design new drugs that concomitantly retards many different resistance strains of HIV.
“We predict that it will be substantially more difficult for the virus to escape a retardant that has been designed with use of proteochemometrics compared to the presently used retardants”, says Jarl Wikberg, and continues:
“The pharmaceutical industry has already shown a great interest to our approach and we have great hopes that it, within a relatively short time span, will result in new improved retardants for treatment of HIV/Aids”.
The article, published in PLoS Computational Biology, can be read at: http://dx.doi.org/10.1371/journal.pcbi.0030048
For more information contact Jarl Wikberg, phone: +46 (0)18-471 42 38; cell phone: +46 (0)70-3 449 549; e-mail: Jarl.Wikberg@farmbio.uu.se
Amputees can learn to control a robotic arm with their minds
28.11.2017 | University of Chicago Medical Center
The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
13.12.2017 | Health and Medicine
13.12.2017 | Physics and Astronomy
13.12.2017 | Life Sciences