Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New tool improves prediction of stroke risk

26.01.2007
A new simple scoring system for use by physicians predicts early risk of stroke following a serious condition named transient ischemic attack, known as TIA and also called a "mini-stroke," according to a study published in this week's "Lancet."

The lead author of the study is S. Claiborne Johnston, MD, a neurologist at UCSF Medical Center and associate professor in the UCSF School of Medicine.

About 240,000 TIAs are diagnosed every year in the United States and about 70,000 in the United Kingdom. A TIA is a serious condition caused by temporary reduction in blood and oxygen supply to part of the brain that can cause acute symptoms such as loss of vision, leg and arm weakness, slurring of speech and loss of consciousness. A TIA is sometimes called a mini-stroke because symptoms are the same as a stroke. The severe symptoms of TIA normally last up to a few hours, and all symptoms disappear within 24 hours. Because of the short duration, many people who experience TIAs do not go to see a doctor, or if they do, they are not always treated with urgency.

Recent studies have shown that 4–20 percent of these patients will have a stroke within 90 days of a TIA, and half within the first two days. Identification of those at highest and lowest risk of stroke after a TIA would help physicians decide who needs to come into the hospital right away and who can be treated as an outpatient, according to Johnston. However, it has not been possible to estimate individual risk with sufficient accuracy to guide these clinical decisions.

Two current prognostic scores have been proposed: the California score, which estimates the risk of stroke within 90 days after presentation of TIA, and the ABCD score, which estimates the risk within seven days. However, Johnston emphasized, estimating the risk of stroke within two days after TIA is often most relevant for decisions about necessity of urgent evaluation and observation.

Johnston and colleagues tested the two existing prognostic scores in large independent groups from different populations from the U.S. and the U.K., comparing predictions of stroke risk at two, seven and 90 days after TIA. Since both previous prognostic scores predicted stroke risk reliably across a wide range of populations and contained several similar components, the researchers generated a new unified score for optimum two-day risk. The new score, ABCD-squared, was a more accurate predictor of risk of stroke than either of the two previous scores, creating a single standard for use in clinical care and public education.

"Right now, there is no consensus as to who gets admitted to the hospital or has other medical intervention after a TIA," Johnston said. "We are hoping this will be a useful tool for emergency department physicians as well as those in clinics." He added that this would also be useful for patients, especially those with diabetes and the elderly.

This new scoring method assigns points to each patient on the basis of five clinical features: high blood pressure, unilateral weakness, speech impairment without weakness, diabetes and being older. The sum of the points delineate groups at high, moderate, or low-risk.

Johnston noted that while intervention such as hospitalization is costly, in the long run it could result in a cost savings because follow-up to a stroke usually involves lengthy and costly inpatient rehabilitation. Also, if the patient does have a stroke while he or she is being observed, the stroke can be treated with clot-busting drugs immediately.

In the "Lancet" report, the authors conclude: "Findings of many studies have confirmed that the short-term risk of stroke is raised after TIA. The ABCD2 score allows identification of groups at especially high risk, in whom aggressive evaluation and urgent intervention is clearly justified."

Carol Hyman | EurekAlert!
Further information:
http://www.ucsf.edu/

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>