In a study carried out by a group of Spanish and German scientists a new protein complex that plays an important role in the orchestration of the above-mentioned processes has been discovered. This complex demonstrates the existence of a new control mechanism in the cellular movements involved in the early development (gastrulation).
As an innovative feature, this study, that will be published next Friday, 19th January, at the prestigious scientific journal Science, has used the computer design “in silico” to direct the experimental work, developed by the research group of the Spanish scientist Luis Serrano. This has allowed avoiding the tedious lab trials that, in many cases, don’t lead anywhere and/or are redundant. Particularly, the use of protein design software and structural information has allowed sifting the genome of the vinegar fly (Drosophila) and predicting the interaction of two proteins (T48 y RhoGEF2).
The use of protein design software to predict the protein-protein or protein-DNA interaction opens de door to discovering other protein-protein interactions and, the most important aspect for human health, predicting the functional effect of variations in the human genome with implications in the customized medicine.
As for the identification of a new regulation pathway of the gastrulation process in the development of the vinegar fly, it will allow to look for similar mechanisms in human individuals that might be involved in embryonic malformations related to cellular migratory processes.
The study has been directed by Maria Leptin, from the University of Cologne, in Germany. The design and prediction aspects have been developed by the Spanish scientists Luis Serrano, who has just left the leadership of the Structural and Computational Biology programme at the European Molecular Biology Laboratory (EMBL) to lead the Systems Biology programme at the Centre for Genomic Regulation, in Barcelona, and Gregorio Fernández, from the Cellular and Molecular Biology Institute, of the University Miguel Hernández, in Elche.
Gloria Lligadas | alfa
Do microplastics harbour additional risks by colonization with harmful bacteria?
05.04.2018 | Leibniz-Institut für Ostseeforschung Warnemünde
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
23.04.2018 | Physics and Astronomy
23.04.2018 | Physics and Astronomy
23.04.2018 | Trade Fair News