Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study finds limited options for backup HIV treatment in some developing countries

11.01.2007
Thai researchers have discovered that patients who fail treatment with a commonly used, inexpensive, first-line antiretroviral therapy (ART) are also usually resistant to other, similar drugs, leaving progressively fewer options for replacement therapies.

Since catching treatment failure early is key to preventing further resistance, this research, published in the Feb. 1 issue of Clinical Infectious Diseases and currently available online, also argues for greater access in the developing world to tests that detect when the amount of virus in a patient's blood is increasing.

Combined antiretroviral therapy has dramatically changed the course of HIV disease, with a substantial reduction in illness and death both in developed and in developing nations. In Thailand, where a 2004 estimate put the number of HIV-infected people at 600,000, a generic, fixed-dose, combined pill of three antiretroviral agents has been available since 2002. In 2004, it was estimated that 60,000 Thai citizens would take this combination of stavudine, lamivudine, and nevirapine, known as d4T/3TC/NVP.

Lead author Somnuek Sungkanurparph, MD, of Ramathibodi Hospital in Thailand, and co-authors found that when this combination stopped working, it was nearly always because the virus had developed mutations that also make useless several other drugs of the same type.

Ideally, if a patient developed resistance to one or more of the elements in d4T/3TC/NVP, then he or she would simply switch to a different combination of drugs. However, in Thailand and other resource-limited countries, economics often determines what types of drugs are available. Some drugs that, in a developed country, might serve as a second regimen are either unaffordable or unavailable.

A small number of drugs do exist that are available and affordable in Thailand and that could serve as a second regimen--if the drug-resistant virus is caught before it gets out of hand. Dr. Sungkanurparph found that when levels of virus in patients' blood were high, nearly two-thirds of them developed multiple drug resistance that limited the options for second-line therapy. When levels were low, only about one-third did.

Unfortunately, the test to detect how much virus is in a patient's blood is not widely available or affordable in many developing countries. Without this tool, which allows early detection of treatment failure, physicians can not change antiretroviral medications in time to stay ahead of resistance. In order to prevent sickness and death from HIV in developing countries, the accessibility of both ART and the virus-detection test need to be increased.

"In settings where antiretroviral agents are limited, prevention strategies for HIV resistance are crucial," said Dr. Sungkanurparph. "Early detection of virological failure provides more options for the second regimen and better treatment outcomes."

Steve Baragona | EurekAlert!
Further information:
http://www.idsociety.org

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>